PMID- 11554555
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20191210
IS  - 1389-4501 (Print)
IS  - 1389-4501 (Linking)
VI  - 2
IP  - 3
DP  - 2001 Sep
TI  - Structure-function relationships of the NMDA receptor antagonist conantokin 
      peptides.
PG  - 313-22
AB  - The three members of the conantokin peptide family identified to date are 
      conantokin(con)-G, -T and -R. Their defining attributes include a high relative 
      content of gamma-carboxyglutamic acid (Gla), N-terminal sequence identity, as 
      well as considerable overall sequence homology, and antagonism of the 
      N-methyl-D-aspartate receptor (NMDAR). As promising templates for the design of 
      neuroprotective agents, a thorough evaluation of structure-function relationships 
      in these peptides will be invaluable in aiding rational drug modeling. To this 
      end, a comprehensive assessment of the contributions of individual residues to 
      conantokin structure and function is required. The current review summarizes 
      recent efforts in this area, and also includes the effects of peptide length, as 
      well as structural-stabilization and -destabilization on the structural and 
      inhibitory profiles of an extensive panel ofconantokin derivatives.
FAU - Prorok, M
AU  - Prorok M
AD  - Department of Chemistry and Biochemistry, and the W.M.Keck Center for Transgene 
      Research, University of Notre Dame, Indiana 46556, USA.
FAU - Castellino, F J
AU  - Castellino FJ
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United Arab Emirates
TA  - Curr Drug Targets
JT  - Current drug targets
JID - 100960531
RN  - 0 (Conotoxins)
RN  - 0 (Excitatory Amino Acid Antagonists)
RN  - 0 (Intercellular Signaling Peptides and Proteins)
RN  - 0 (Mollusk Venoms)
RN  - 0 (Peptides)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (conantokin R)
RN  - 127476-26-0 (conantokin-T)
RN  - 93438-65-4 (conotoxin GV)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Conotoxins/chemistry/*pharmacology
MH  - Excitatory Amino Acid Antagonists/chemistry/*pharmacology
MH  - Humans
MH  - Intercellular Signaling Peptides and Proteins
MH  - Molecular Sequence Data
MH  - Mollusk Venoms/chemistry/*pharmacology
MH  - Peptides/chemistry/*pharmacology
MH  - Receptors, N-Methyl-D-Aspartate/*antagonists & inhibitors
MH  - Structure-Activity Relationship
RF  - 43
EDAT- 2001/09/14 10:00
MHDA- 2002/02/20 10:01
CRDT- 2001/09/14 10:00
PHST- 2001/09/14 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2001/09/14 10:00 [entrez]
AID - 10.2174/1389450013348542 [doi]
PST - ppublish
SO  - Curr Drug Targets. 2001 Sep;2(3):313-22. doi: 10.2174/1389450013348542.