PMID- 11555724
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20190915
IS  - 1040-8711 (Print)
IS  - 1040-8711 (Linking)
VI  - 13
IP  - 4
DP  - 2001 Jul
TI  - Cytokine gene polymorphisms relevant for the spondyloarthropathies.
PG  - 250-4
AB  - Results of sibling and twin studies suggest that a substantial proportion of 
      susceptibility to spondyloarthropathies arises from genes outside the human 
      leukocyte antigen (HLA) region. There is increasing evidence that the pattern of 
      cytokine secretion influences the course of spondyloarthropathies. A Th2 cytokine 
      pattern (low tumor necrosis factor [TNF]-TNF-alpha low interferon [IFN]-gamma, 
      and high interleukin [IL]-10) dominates in the joints of reactive arthritis 
      patients. For IL-10 and TNF-alpha a substantial proportion of cytokine production 
      is under genetic control and influenced by genetic polymorphisms. Here we review 
      the evidences for association of TNF-alpha and IL-10 polymorphisms with 
      spondyloarthropathies and their functional implications.
FAU - Rudwaleit, M
AU  - Rudwaleit M
AD  - Medizinische Klinik I, Universitatsklinikum Benjamin Franklin, Berlin, Germany.
FAU - Hohler, T
AU  - Hohler T
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Rheumatol
JT  - Current opinion in rheumatology
JID - 9000851
RN  - 0 (Cytokines)
SB  - IM
MH  - Arthritis, Psoriatic/genetics/immunology
MH  - Arthritis, Reactive/genetics/immunology
MH  - Cytokines/*genetics
MH  - Humans
MH  - Polymorphism, Genetic/*immunology
MH  - Spondylitis, Ankylosing/*genetics/*immunology
RF  - 51
EDAT- 2001/09/14 10:00
MHDA- 2001/10/12 10:01
CRDT- 2001/09/14 10:00
PHST- 2001/09/14 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/09/14 10:00 [entrez]
AID - 10.1097/00002281-200107000-00002 [doi]
PST - ppublish
SO  - Curr Opin Rheumatol. 2001 Jul;13(4):250-4. doi: 10.1097/00002281-200107000-00002.