PMID- 11556685
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20210904
IS  - 1015-6305 (Print)
IS  - 1750-3639 (Electronic)
IS  - 1015-6305 (Linking)
VI  - 11
IP  - 4
DP  - 2001 Oct
TI  - Prevalence of HSV-1 LAT in human trigeminal, geniculate, and vestibular ganglia 
      and its implication for cranial nerve syndromes.
PG  - 408-13
AB  - Herpes simplex virus type 1 (HSV-1) enters sensory neurons and can remain latent 
      there until reactivation. During latency restricted HSV-1 gene expression takes 
      place in the form of latency-associated transcripts (LAT). LAT has been 
      demonstrated to be important not only for latency but also for reactivation, 
      which may cause cranial nerve disorders. Tissue sections of the trigeminal 
      ganglia (TG), geniculate ganglia (GG), and the vestibular ganglia (VG) from seven 
      subjects were examined for the presence of LAT using the in situ hybridization 
      technique. LAT was found on both sides in allTG (100%), on both sides of five 
      subjects (70%) in the GG, and in none of the VG. Using a second more sensitive 
      detection method (RT-PCR), we found LAT in the VG of seven of ten other persons 
      (70%). This is the first study to demonstrate viral latency in the VG, a finding 
      that supports the hypothesis that vestibular neuritis is caused by HSV-1 
      reactivation. The distribution of LAT in the cranial nerve ganglia indicates that 
      primary infection occurs in the TG and GG and subsequently spreads along the 
      faciovestibular anastomosis to the VG.
FAU - Theil, D
AU  - Theil D
AD  - Department of Neurology, Klinikum Grosshadern, LMU Munich, Germany. 
      dtheil@brain.nefo.med.uni-muenchen.de
FAU - Arbusow, V
AU  - Arbusow V
FAU - Derfuss, T
AU  - Derfuss T
FAU - Strupp, M
AU  - Strupp M
FAU - Pfeiffer, M
AU  - Pfeiffer M
FAU - Mascolo, A
AU  - Mascolo A
FAU - Brandt, T
AU  - Brandt T
LA  - eng
PT  - Journal Article
PL  - Switzerland
TA  - Brain Pathol
JT  - Brain pathology (Zurich, Switzerland)
JID - 9216781
RN  - 0 (ICP27 protein, human herpesvirus 1)
RN  - 0 (Immediate-Early Proteins)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cranial Nerve Diseases/pathology/physiopathology/*virology
MH  - Gene Expression Regulation, Viral/physiology
MH  - Geniculate Ganglion/pathology/physiopathology/*virology
MH  - Herpes Simplex/*genetics/metabolism/pathology
MH  - Herpesvirus 1, Human/*genetics/metabolism/pathogenicity
MH  - Humans
MH  - Immediate-Early Proteins/metabolism
MH  - In Situ Hybridization
MH  - Middle Aged
MH  - RNA, Viral/*metabolism
MH  - Reverse Transcriptase Polymerase Chain Reaction
MH  - Transcription, Genetic/genetics
MH  - Trigeminal Ganglion/pathology/physiopathology/*virology
MH  - Vestibular Nerve/pathology/physiopathology/*virology
MH  - Virus Latency/genetics
PMC - PMC8098601
EDAT- 2001/09/15 10:00
MHDA- 2002/02/22 10:01
PMCR- 2006/04/05
CRDT- 2001/09/15 10:00
PHST- 2001/09/15 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2001/09/15 10:00 [entrez]
PHST- 2006/04/05 00:00 [pmc-release]
AID - BPA408 [pii]
AID - 10.1111/j.1750-3639.2001.tb00408.x [doi]
PST - ppublish
SO  - Brain Pathol. 2001 Oct;11(4):408-13. doi: 10.1111/j.1750-3639.2001.tb00408.x.