PMID- 11556746
OWN - NLM
STAT- MEDLINE
DCOM- 20020213
LR  - 20191105
IS  - 1541-2016 (Print)
IS  - 1533-4058 (Linking)
VI  - 9
IP  - 3
DP  - 2001 Sep
TI  - p53: a good diagnostic marker for intratubular germ cell neoplasia, unclassified.
PG  - 203-6
AB  - Intratubular germ cell neoplasia, unclassified (IGCNU) is a precursor of germ 
      cell tumors (GCT) of the testis. In routine histologic sections, neoplastic 
      intratubular germ cells may be very few and easily overlooked. The aim of this 
      study is two-fold: to establish the immunohistochemical pattern of expression of 
      p53 in IGCNU and GCT and to determine whether p53 can be used as a marker for 
      IGCNU. Resection specimens from 14 seminomas, 14 mixed germ cell tumors (MGCT), 3 
      embryonal carcinomas, 2 mature teratomas, 7 IGCNUs, and 11 normal testes were 
      stained for p53. Normal germ cells and Sertoli cells of the seminiferous tubules 
      in all normal testes were negative for p53. The tumor cells of all IGCNU cases 
      were positive for p53. All invasive components of mixed germ cell tumors, 
      embryonal carcinomas, and seminomas exhibited expression of p53. Mature teratoma 
      components were negative for p53. These findings indicate that p53 is a highly 
      sensitive marker of IGCNU and highly specific in distinguishing lesional tissue 
      from normal seminiferous tubules. The current findings also suggest that p53 may 
      be involved as an early step in the malignant progression of most germ cell 
      neoplasias.
FAU - Moore, B E
AU  - Moore BE
AD  - Department of Pathology, University of Massachusetts Memorial Medical Center, 
      Worcester 01655, USA.
FAU - Banner, B F
AU  - Banner BF
FAU - Gokden, M
AU  - Gokden M
FAU - Woda, B
AU  - Woda B
FAU - Liu, Y
AU  - Liu Y
FAU - Ayala, A
AU  - Ayala A
FAU - Jiang, Z
AU  - Jiang Z
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Appl Immunohistochem Mol Morphol
JT  - Applied immunohistochemistry & molecular morphology : AIMM
JID - 100888796
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Tumor Suppressor Protein p53)
SB  - IM
MH  - Biomarkers, Tumor/*metabolism
MH  - Germinoma/classification/*diagnosis/pathology
MH  - Humans
MH  - Immunohistochemistry
MH  - Male
MH  - Testicular Neoplasms/classification/*diagnosis/pathology
MH  - Tumor Suppressor Protein p53/*metabolism
EDAT- 2001/09/15 10:00
MHDA- 2002/02/14 10:01
CRDT- 2001/09/15 10:00
PHST- 2001/09/15 10:00 [pubmed]
PHST- 2002/02/14 10:01 [medline]
PHST- 2001/09/15 10:00 [entrez]
AID - 10.1097/00129039-200109000-00002 [doi]
PST - ppublish
SO  - Appl Immunohistochem Mol Morphol. 2001 Sep;9(3):203-6. doi: 
      10.1097/00129039-200109000-00002.