PMID- 11556970
OWN - NLM
STAT- MEDLINE
DCOM- 20020117
LR  - 20190826
IS  - 0001-2815 (Print)
IS  - 0001-2815 (Linking)
VI  - 57
IP  - 5
DP  - 2001 May
TI  - HLA class I genotyping including HLA-B*51 allele typing in the Iranian patients 
      with Behcet's disease.
PG  - 457-62
AB  - It is well known that Behcet's disease (BD) is strongly associated with human 
      leukocyte antigen (HLA) B51 in many ethnic groups. However, there has been no 
      published report as yet with respect to this association among the Iranian 
      people. Furthermore, since it is now known that the B51 antigen can be encoded by 
      21 alleles, B*5101-B*5121, we performed HLA-B*51 allele typing as well as HLA 
      class I genotyping of 48 Iranian patients with this disease. As a result, the 
      frequency of the B*51 allele was significantly higher (62.1%) in the patient 
      group as compared with the ethnically matched control group (31.8%) (Pc=0.067, 
      R.R.=3.51). In the genotyping of B*51 alleles, 33 out of the 36 B*51-positive 
      patients possessed B*5101 and the remaining 3 carried B*5108. This study revealed 
      that Iranian patients with BD also had a strong association with HLA-B51. In 
      addition, this significantly high incidence of HLA-B*51 was found to be caused by 
      an increase in both the HLA-B*5101 and HLA-B*5108 alleles. However, there was no 
      significant difference in the HLA-B*51 allelic distribution between the patient 
      and control groups.
FAU - Mizuki, N
AU  - Mizuki N
AD  - Department of Ophthalmology, Yokohama City University School of Medicine, 
      Kanazawa-ku, Yokohama, Kanagawa, Japan.
FAU - Ota, M
AU  - Ota M
FAU - Katsuyama, Y
AU  - Katsuyama Y
FAU - Yabuki, K
AU  - Yabuki K
FAU - Ando, H
AU  - Ando H
FAU - Yoshida, M
AU  - Yoshida M
FAU - Onari, K
AU  - Onari K
FAU - Nikbin, B
AU  - Nikbin B
FAU - Davatchi, F
AU  - Davatchi F
FAU - Chams, H
AU  - Chams H
FAU - Ghaderi, A A
AU  - Ghaderi AA
FAU - Ohno, S
AU  - Ohno S
FAU - Inoko, H
AU  - Inoko H
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Tissue Antigens
JT  - Tissue antigens
JID - 0331072
RN  - 0 (HLA-A Antigens)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B51 Antigen)
SB  - IM
MH  - *Alleles
MH  - Behcet Syndrome/*genetics/*immunology
MH  - Genes, MHC Class I/*genetics
MH  - Genotype
MH  - HLA-A Antigens/genetics
MH  - HLA-B Antigens/*genetics
MH  - HLA-B51 Antigen
MH  - Histocompatibility Testing/*methods
MH  - Humans
MH  - Iran
MH  - Phenotype
EDAT- 2001/09/15 10:00
MHDA- 2002/01/18 10:01
CRDT- 2001/09/15 10:00
PHST- 2001/09/15 10:00 [pubmed]
PHST- 2002/01/18 10:01 [medline]
PHST- 2001/09/15 10:00 [entrez]
AID - tan570507 [pii]
AID - 10.1034/j.1399-0039.2001.057005457.x [doi]
PST - ppublish
SO  - Tissue Antigens. 2001 May;57(5):457-62. doi: 
      10.1034/j.1399-0039.2001.057005457.x.