PMID- 11557103
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190901
IS  - 0165-3806 (Print)
IS  - 0165-3806 (Linking)
VI  - 130
IP  - 1
DP  - 2001 Sep 23
TI  - Elevation of fetal dopamine following exposure to methamphetamine in utero.
PG  - 139-42
AB  - The effect of methamphetamine on fetal dopaminergic function was examined 
      following treatment of pregnant mice twice daily with 40 mg/kg methamphetamine 
      from either gestational day (GD) 7-13 or from GD 7-15. Dopamine levels were 
      elevated in fetal GD 16 corpus striatum and rostral mesencephalon following both 
      treatment regimens. This increase in fetal dopamine is consistent with our 
      findings that exposure to methamphetamine in utero results in adult dopaminergic 
      neurons which are more responsive in terms of methamphetamine induced release of 
      the neurotransmitter and more sensitive to the neurotoxic effects of the drug.
FAU - Heller, A
AU  - Heller A
AD  - Department of Neurobiology, Pharmacology and Physiology, The University of 
      Chicago, 947 East 58th Street, Chicago, IL 60637, USA. effe@midway.uchicago.u
FAU - Bubula, N
AU  - Bubula N
FAU - Freeney, A
AU  - Freeney A
FAU - Won, L
AU  - Won L
LA  - eng
GR  - DA-09764/DA/NIDA NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - Brain Res Dev Brain Res
JT  - Brain research. Developmental brain research
JID - 8908639
RN  - 0 (Dopamine Agents)
RN  - 44RAL3456C (Methamphetamine)
RN  - VTD58H1Z2X (Dopamine)
SB  - IM
MH  - Animals
MH  - Corpus Striatum/*drug effects/metabolism
MH  - Dopamine/*metabolism
MH  - Dopamine Agents/*pharmacology
MH  - Female
MH  - Fetus/metabolism
MH  - Methamphetamine/*pharmacology
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pregnancy
MH  - Substantia Nigra/*drug effects/metabolism
EDAT- 2001/09/15 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/15 10:00
PHST- 2001/09/15 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/15 10:00 [entrez]
AID - S016538060100222X [pii]
AID - 10.1016/s0165-3806(01)00222-x [doi]
PST - ppublish
SO  - Brain Res Dev Brain Res. 2001 Sep 23;130(1):139-42. doi: 
      10.1016/s0165-3806(01)00222-x.