PMID- 11559502
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20210604
IS  - 0195-6108 (Print)
IS  - 1936-959X (Electronic)
IS  - 0195-6108 (Linking)
VI  - 22
IP  - 8
DP  - 2001 Sep
TI  - Xenon-induced flow activation in patients with cerebral insult who undergo 
      xenon-enhanced CT blood flow studies.
PG  - 1543-9
AB  - BACKGROUND AND PURPOSE: Stable xenon-enhanced CT ((s)Xe/CT) has gained wide 
      acceptance in the assessment of regional cerebral blood flow (rCBF) in patients 
      with intracranial abnormalities. The aim of this study was to test whether the 
      contrast medium (ie, (s)Xe) itself directly induces relevant changes in rCBF, 
      thereby distorting any valid determination of cerebral perfusion by using 
      (s)Xe/CT. METHODS: To characterize the degree and temporal dynamics of 
      (s)Xe-induced flow activation, a thermal diffusion (TD)-based microprobe was 
      placed subcortically into the frontal lobe on either hemisphere to assess rCBF 
      (TD-rCBF) continuously in 23 patients (mean age, 55 +/- 18 years) with severe 
      intracranial insult who were undergoing (s)Xe/CT. RESULTS: In 35, the (s)Xe/CT 
      studies TD-rCBF rose from 25 +/- 17 mL/100 g per minute (range, 5-42 mL/100 g per 
      minute) before (s)Xe administration to 28 +/- 21 mL/100 g per minute (range, 6-46 
      mL/100 g per minute) after arterial (s)Xe saturation was reached. Analysis of the 
      flow activation curve showed a logarithmic shape with an increase in TD-rCBF 
      between 3% and 7% within the first 76 seconds of (s)Xe wash-in (12% after 190 
      seconds) and showed no further augmentation until the end of the blood flow 
      study. CONCLUSION: The observed (s)Xe-induced rCBF activation, which showed 
      significant inter- and intraindividual variability, might lead to overestimation 
      of rCBF in patients with severe intracranial insult. The obtained flow activation 
      curve provides essential information that may allow subsequent refinement of the 
      methodology, aiming to further minimize the influence of (s)Xe-induced rCBF 
      activation on rCBF calculations when using (s)Xe/CT technology.
FAU - Horn, P
AU  - Horn P
AD  - Department of Neurosurgery, University Hospital Mannheim, Faculty of Clinical 
      Medicine, University Heidelberg, Mannheim, Germany.
FAU - Vajkoczy, P
AU  - Vajkoczy P
FAU - Thome, C
AU  - Thome C
FAU - Muench, E
AU  - Muench E
FAU - Schilling, L
AU  - Schilling L
FAU - Schmiedek, P
AU  - Schmiedek P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - AJNR Am J Neuroradiol
JT  - AJNR. American journal of neuroradiology
JID - 8003708
RN  - 3H3U766W84 (Xenon)
SB  - IM
MH  - Administration, Inhalation
MH  - Adult
MH  - Aged
MH  - Brain Injuries/*diagnosis/*physiopathology
MH  - *Cerebrovascular Circulation/drug effects
MH  - Female
MH  - Humans
MH  - Intracranial Pressure
MH  - Male
MH  - Middle Aged
MH  - Subarachnoid Hemorrhage/*diagnosis/*physiopathology
MH  - *Tomography, X-Ray Computed
MH  - *Xenon/administration & dosage/pharmacology
PMC - PMC7974584
EDAT- 2001/09/18 10:00
MHDA- 2001/10/26 10:01
PMCR- 2002/09/01
CRDT- 2001/09/18 10:00
PHST- 2001/09/18 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/09/18 10:00 [entrez]
PHST- 2002/09/01 00:00 [pmc-release]
PST - ppublish
SO  - AJNR Am J Neuroradiol. 2001 Sep;22(8):1543-9.