PMID- 11559960
OWN - NLM
STAT- MEDLINE
DCOM- 20011213
LR  - 20220321
IS  - 1065-9471 (Print)
IS  - 1097-0193 (Electronic)
IS  - 1065-9471 (Linking)
VI  - 14
IP  - 3
DP  - 2001 Nov
TI  - Localization of MDMA-induced brain activity in healthy volunteers using low 
      resolution brain electromagnetic tomography (LORETA).
PG  - 152-65
AB  - 3,4-Methylenedioxymethamphetamine (MDMA; 'Ecstasy') is a psychostimulant drug 
      producing heightened mood and facilitated social communication. In animal 
      studies, MDMA effects are primarily mediated by serotonin (5-HT), but also by 
      dopamine (DA) and possibly noradrenaline (NA). In humans, however, the 
      neurochemical and neurophysiological basis of acute MDMA effects remains unknown. 
      The distribution of active neuronal populations after administration of a single 
      dose of MDMA (1.7 mg/kg) or placebo was studied in 16 healthy, MDMA-naive 
      volunteers. Thirty-one-channel scalp EEGs during resting with open and closed 
      eyes was analyzed in the different EEG frequency bands. Scalp maps of power 
      showed significant, global differences between MDMA and placebo in both eye 
      conditions and all frequency bands. Low resolution brain electromagnetic 
      tomography (LORETA) was used to compute 3D, functional images of electric 
      neuronal activity from the scalp EEG data. MDMA produced a widespread decrease of 
      slow and medium frequency activity and an increase of fast frequency activity in 
      the anterior temporal and posterior orbital cortex, concomitant with a marked 
      enhancement of mood, emotional arousal and increased extraversion. This 
      activation of frontotemporal areas indicates that the observed enhancement of 
      mood and possibly the increased extroversion rely on modulation of limbic 
      orbitofrontal and anterotemporal structures known to be involved in emotional 
      processes. Comparison of the MDMA-specific EEG pattern with that of various 5-HT, 
      DA, and NA agonists indicates that serotonin, noradrenaline, and, to a lesser 
      degree, dopamine, contribute to the effects of MDMA on EEG, and possibly also on 
      mood and behavior.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Frei, E
AU  - Frei E
AD  - University Hospital of Psychiatry, Zurich, Switzerland.
FAU - Gamma, A
AU  - Gamma A
FAU - Pascual-Marqui, R
AU  - Pascual-Marqui R
FAU - Lehmann, D
AU  - Lehmann D
FAU - Hell, D
AU  - Hell D
FAU - Vollenweider, F X
AU  - Vollenweider FX
LA  - eng
PT  - Clinical Trial
PT  - Journal Article
PT  - Randomized Controlled Trial
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Hum Brain Mapp
JT  - Human brain mapping
JID - 9419065
RN  - 0 (Hallucinogens)
RN  - 0 (Neurotransmitter Agents)
RN  - 0 (Receptors, Neurotransmitter)
RN  - KE1SEN21RM (N-Methyl-3,4-methylenedioxyamphetamine)
SB  - IM
MH  - Action Potentials/*drug effects/physiology
MH  - Adult
MH  - Affect/drug effects/physiology
MH  - Brain Mapping
MH  - Cerebral Cortex/*drug effects/metabolism/physiopathology
MH  - Electroencephalography/*drug effects
MH  - Electromagnetic Phenomena
MH  - Euphoria/drug effects/physiology
MH  - Female
MH  - Functional Laterality/drug effects/physiology
MH  - Hallucinogens/administration & dosage/*adverse effects
MH  - Humans
MH  - Limbic System/drug effects/metabolism/physiopathology
MH  - Male
MH  - N-Methyl-3,4-methylenedioxyamphetamine/administration & dosage/*adverse effects
MH  - Neurotransmitter Agents/*agonists/metabolism
MH  - Photic Stimulation
MH  - Receptors, Neurotransmitter/*drug effects/metabolism
MH  - Sensory Deprivation/physiology
MH  - Visual Perception/drug effects/physiology
PMC - PMC6872058
EDAT- 2001/09/18 10:00
MHDA- 2002/01/05 10:01
PMCR- 2001/08/27
CRDT- 2001/09/18 10:00
PHST- 2001/09/18 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/18 10:00 [entrez]
PHST- 2001/08/27 00:00 [pmc-release]
AID - 10.1002/hbm.1049 [pii]
AID - HBM1049 [pii]
AID - 10.1002/hbm.1049 [doi]
PST - ppublish
SO  - Hum Brain Mapp. 2001 Nov;14(3):152-65. doi: 10.1002/hbm.1049.