PMID- 11565077
OWN - NLM
STAT- MEDLINE
DCOM- 20011212
LR  - 20220331
IS  - 1058-4838 (Print)
IS  - 1058-4838 (Linking)
VI  - 33
IP  - 8
DP  - 2001 Oct 15
TI  - Association of human herpesvirus 6 reactivation with severe 
      cytomegalovirus-associated disease in orthotopic liver transplant recipients.
PG  - 1358-62
AB  - To explore the possible interaction between human herpesvirus 6 (HHV-6) and 
      cytomegalovirus (CMV) in patients who have undergone organ transplantation, 
      stored serum samples from 139 orthotopic liver transplant recipients were tested 
      for HHV-6 immunoglobulin (Ig) G and IgM antibodies. HHV-6 reactivation occurred 
      in 87 patients (62.6%) and was associated with CMV disease (P=.01), severe 
      CMV-associated disease (P=.01), older age (P=.005), and use of muromonab-CD3 
      (Orthoclone; Orthobiotech) as treatment for rejection (P=.02). Trends for an 
      association between HHV-6 reactivation and invasive fungal disease (P=.12), 
      bacteremia (P=.10), and graft loss (P=.12) were seen. In a multivariate analysis 
      of risk factors for severe CMV-associated disease, HHV-6 reactivation (relative 
      risk [RR], 3.5; 95% confidence interval [CI], 1.2-10.2; P=.02), CMV 
      donor-positive-recipient-negative match (RR, 5.7; 95% CI, 2.5-13.2; P<.001), and 
      elevated serum creatinine level (P<.0001) were independent predictors. HHV-6 
      reactivation is associated with severe CMV-associated disease in liver transplant 
      recipients.
FAU - DesJardin, J A
AU  - DesJardin JA
AD  - Department of Medicine, New England Medical Center, Boston, MA 02111, USA.
FAU - Cho, E
AU  - Cho E
FAU - Supran, S
AU  - Supran S
FAU - Gibbons, L
AU  - Gibbons L
FAU - Werner, B G
AU  - Werner BG
FAU - Snydman, D R
AU  - Snydman DR
LA  - eng
GR  - AI-07329/AI/NIAID NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20010920
PL  - United States
TA  - Clin Infect Dis
JT  - Clinical infectious diseases : an official publication of the Infectious Diseases 
      Society of America
JID - 9203213
RN  - 0 (Antibodies, Viral)
SB  - IM
MH  - Adult
MH  - Antibodies, Viral/blood
MH  - Cytomegalovirus/immunology
MH  - Cytomegalovirus Infections/*complications/diagnosis/virology
MH  - Female
MH  - Herpesviridae Infections/*diagnosis/virology
MH  - Herpesvirus 6, Human/*growth & development/immunology
MH  - Humans
MH  - Liver Transplantation/*adverse effects
MH  - Male
MH  - Middle Aged
MH  - Retrospective Studies
MH  - *Virus Activation
EDAT- 2001/09/21 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/21 10:00
PHST- 2000/12/22 00:00 [received]
PHST- 2001/05/02 00:00 [revised]
PHST- 2001/09/21 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/21 10:00 [entrez]
AID - CID001732 [pii]
AID - 10.1086/323336 [doi]
PST - ppublish
SO  - Clin Infect Dis. 2001 Oct 15;33(8):1358-62. doi: 10.1086/323336. Epub 2001 Sep 
      20.