PMID- 11566180
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20190621
IS  - 0014-5793 (Print)
IS  - 0014-5793 (Linking)
VI  - 505
IP  - 2
DP  - 2001 Sep 14
TI  - ATRA-regulated Asb-2 gene induced in differentiation of HL-60 leukemia cells.
PG  - 223-8
AB  - Suppressors of cytokine signaling (SOCS) proteins possess common structures, a 
      SOCS box at the C-terminus and a SH2 domain at their center. These suppressors 
      are inducible in response to cytokines and act as negative regulators of cytokine 
      signaling. The ASB proteins also contain the SOCS box and the ankyrin repeat 
      sequence at the N-terminus, but do not have the SH2 domain. Although Socs genes 
      are directly induced by several cytokines, no Asb gene inducers have been 
      identified. In this study, we screened the specific genes expressed in the course 
      of differentiation of HL-60 cells, and demonstrated that ASB-2, one of the ASB 
      proteins, was rapidly induced by all-trans retinoic acid (ATRA). Typical retinoid 
      receptors (RARs) or retinoid X receptors (RXRs) binding element (RARE/RXRE) were 
      presented in the promoter of the Asb-2 gene. We showed that RARalpha, one of the 
      RARs, binds to the RARE/RXRE in the Asb-2 promoter. In addition, we demonstrated 
      by luciferase reporter assay that this element was a functional RARE/RXRE. These 
      findings indicate that ASB-2 is directly induced by ATRA and may act as a 
      significant regulator, underlying such physiological processes as cell 
      differentiation.
FAU - Kohroki, J
AU  - Kohroki J
AD  - Graduate School of Pharmaceutical Science, Osaka University, Yamada-oka 1-6, 
      Suita, Osaka 565-0871, Japan.
FAU - Fujita, S
AU  - Fujita S
FAU - Itoh, N
AU  - Itoh N
FAU - Yamada, Y
AU  - Yamada Y
FAU - Imai, H
AU  - Imai H
FAU - Yumoto, N
AU  - Yumoto N
FAU - Nakanishi, T
AU  - Nakanishi T
FAU - Tanaka, K
AU  - Tanaka K
LA  - eng
PT  - Journal Article
PL  - England
TA  - FEBS Lett
JT  - FEBS letters
JID - 0155157
RN  - 0 (ASB2 protein, human)
RN  - 0 (Adaptor Proteins, Signal Transducing)
RN  - 0 (Carrier Proteins)
RN  - 0 (Cytokines)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, Retinoic Acid)
RN  - 0 (Suppressor of Cytokine Signaling Proteins)
RN  - 5688UTC01R (Tretinoin)
RN  - EC 1.13.12.- (Luciferases)
SB  - IM
MH  - *Adaptor Proteins, Signal Transducing
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - Blotting, Northern
MH  - Blotting, Western
MH  - Carrier Proteins/*biosynthesis/*chemistry
MH  - Cell Differentiation
MH  - Cell Division
MH  - Cell Line
MH  - Cytokines/metabolism
MH  - Gene Expression Profiling
MH  - Gene Expression Regulation, Neoplastic
MH  - HL-60 Cells
MH  - Humans
MH  - Luciferases/metabolism
MH  - Mice
MH  - Molecular Sequence Data
MH  - Promoter Regions, Genetic
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/metabolism
MH  - Receptors, Retinoic Acid/metabolism
MH  - Signal Transduction
MH  - Suppressor of Cytokine Signaling Proteins
MH  - Time Factors
MH  - Transfection
MH  - Tretinoin/*pharmacology
EDAT- 2001/09/22 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/09/22 10:00
PHST- 2001/09/22 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/09/22 10:00 [entrez]
AID - S0014-5793(01)02829-0 [pii]
AID - 10.1016/s0014-5793(01)02829-0 [doi]
PST - ppublish
SO  - FEBS Lett. 2001 Sep 14;505(2):223-8. doi: 10.1016/s0014-5793(01)02829-0.