PMID- 11566495
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20190720
IS  - 0304-3835 (Print)
IS  - 0304-3835 (Linking)
VI  - 172
IP  - 2
DP  - 2001 Oct 30
TI  - Cyclin D1 amplification correlates with early recurrence of squamous cell 
      carcinoma of the tongue.
PG  - 187-92
AB  - Amplification of CCND1 was studied in 23 tongue carcinoma patients by 
      fluorescence in situ hybridization (FISH) using a paraffin embedded specimen. All 
      the patients received complete resection of the primary site with or without neck 
      dissection. CCND1 amplification was positive in 13 (56.5%) out of 23 cases. 
      Correlations between CCND1 amplification and histological grading, T category, N 
      category, and Stages were not significant. The 5-year disease-free survival rate, 
      which was 23.1% for CCND1 amplification positive patients and 80.0% for negative 
      patients, was significantly better for the CCND1 amplification negative patients 
      (P=0.0070). Nine patients were examined by dual-color FISH with the probe for 
      centromere of chromosome 11 and 11q13. In five patients, who had positive 
      amplification for CCND1, cell numbers with a larger number of signals for 11q13 
      than the centromere of chromosome 11 were significantly higher than those of 
      CCND1 amplification negative patients (P=0.013). This indicates that 
      amplification of 11q13 occurs more frequently than aberration of chromosome 11 in 
      CCND1 amplification positive patients. From these results, the amplification of 
      CCND1 is a key factor in predicting the aggressiveness of tongue cancer. 
      Furthermore, FISH proved to be a useful method for such evaluation.
FAU - Fujii, M
AU  - Fujii M
AD  - Department of Otolaryngology, Keio University School of Medicine, 35 Shinanomachi 
      Shinjuku, 1608582, Tokyo, Japan. mfujii@med.keio.ac.jp
FAU - Ishiguro, R
AU  - Ishiguro R
FAU - Yamashita, T
AU  - Yamashita T
FAU - Tashiro, M
AU  - Tashiro M
LA  - eng
PT  - Journal Article
PL  - Ireland
TA  - Cancer Lett
JT  - Cancer letters
JID - 7600053
RN  - 136601-57-5 (Cyclin D1)
SB  - IM
MH  - Carcinoma, Squamous Cell/*genetics/mortality
MH  - Chromosomes, Human, Pair 11
MH  - Cohort Studies
MH  - Cyclin D1/*genetics
MH  - Female
MH  - *Gene Amplification
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - *Neoplasm Recurrence, Local
MH  - Prognosis
MH  - Retrospective Studies
MH  - Survival Rate
MH  - Tongue Neoplasms/*genetics/mortality
EDAT- 2001/09/22 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/09/22 10:00
PHST- 2001/09/22 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/09/22 10:00 [entrez]
AID - S0304383501006516 [pii]
AID - 10.1016/s0304-3835(01)00651-6 [doi]
PST - ppublish
SO  - Cancer Lett. 2001 Oct 30;172(2):187-92. doi: 10.1016/s0304-3835(01)00651-6.