PMID- 11566508
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190712
IS  - 0306-4522 (Print)
IS  - 0306-4522 (Linking)
VI  - 106
IP  - 2
DP  - 2001
TI  - Differential induction of brain-derived neurotrophic factor mRNA in rat inferior 
      olive subregions following unilateral labyrinthectomy.
PG  - 385-94
AB  - Vestibular compensation, the neuronal process underlying behavioral recovery from 
      vestibular dysfunction produced by unilateral labyrinthectomy, is attributed to 
      functional reorganization of neuronal circuits in the brainstem and cerebellum. 
      Climbing fibers originating from the inferior olive are suggested to play a 
      crucial role in this compensatory process. To assess the possible contribution of 
      brain-derived neurotrophic factor (BDNF) to the function of climbing fibers 
      during vestibular compensation, we investigated the BDNF mRNA expression in the 
      rat inferior olive after unilateral labyrinthectomy by quantitative in situ 
      hybridization. We found several induction patterns depending on the subregions of 
      the inferior olive 6 h after unilateral labyrinthectomy. First, in the dorsal cap 
      and the ventrolateral outgrowth, the expression levels increased on the side 
      contralateral to the lesion and decreased on the ipsilateral side. Second, in the 
      beta nucleus, C subnucleus of the medial accessory olive, and A/B subnuclei of 
      the medial accessory olive, we detected an increase in the mRNA expression level 
      on the side contralateral to the lesion, but no changes in the expression level 
      on the ipsilateral side. In the beta nucleus, where the strongest induction was 
      observed, the mRNA expression level increased nearly five-fold. Third, in the 
      dorsomedial cell column, the mRNA expression levels increased on both sides. 
      Finally, we did not detect significant changes in mRNA expression levels in the 
      other subregions of the inferior olive, the dorsal accessory olive, principal 
      olive and rostral medial accessory olive. The changes in BDNF mRNA expression 
      reverted to control levels by 72 h after the labyrinthectomy. The inferior olive 
      subregions that showed changes in BDNF mRNA expression levels send climbing 
      fibers to the cerebellar cortical regions that, in turn, project to the 
      vestibular nuclei. Therefore, BDNF induced in these subregions could contribute 
      to the functional reorganization of the olivo-cerebellar system for vestibular 
      control.
FAU - Li, Y X
AU  - Li YX
AD  - Mind Articulation Project, ICORP, JST, 4-9-2 Yushima, Tokyo 113-0034, Japan.
FAU - Tokuyama, W
AU  - Tokuyama W
FAU - Okuno, H
AU  - Okuno H
FAU - Miyashita, Y
AU  - Miyashita Y
FAU - Hashimoto, T
AU  - Hashimoto T
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neuroscience
JT  - Neuroscience
JID - 7605074
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*genetics
MH  - Cerebellum/cytology/*metabolism
MH  - Gene Expression/physiology
MH  - Image Processing, Computer-Assisted/instrumentation/methods
MH  - In Situ Hybridization
MH  - Male
MH  - Neural Pathways/cytology/*metabolism
MH  - Neuronal Plasticity/*physiology
MH  - Olivary Nucleus/cytology/*metabolism
MH  - RNA, Messenger/*metabolism
MH  - Rats
MH  - Rats, Wistar
MH  - Recovery of Function/physiology
MH  - Up-Regulation/physiology
MH  - Vestibular Diseases/*physiopathology
MH  - Vestibule, Labyrinth/injuries/physiopathology/surgery
EDAT- 2001/09/22 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/22 10:00
PHST- 2001/09/22 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/22 10:00 [entrez]
AID - S0306-4522(01)00194-4 [pii]
AID - 10.1016/s0306-4522(01)00194-4 [doi]
PST - ppublish
SO  - Neuroscience. 2001;106(2):385-94. doi: 10.1016/s0306-4522(01)00194-4.