PMID- 11567594
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20191210
IS  - 0742-2822 (Print)
IS  - 0742-2822 (Linking)
VI  - 18
IP  - 6
DP  - 2001 Aug
TI  - Evaluation of the response to pharmacological stress in chronic aortic 
      regurgitation.
PG  - 491-6
AB  - We evaluated the hemodynamic response of patients with chronic aortic 
      regurgitation and decreased ejection fraction (EF), mean value +/- SD (37 +/- 9), 
      to dobutamine stress echocardiography (DSE). Eleven patients were studied with 
      DSE. Nine patients were in New York Heart Association (NYHA) Class II and two in 
      NYHA Class III. Ten patients received medical treatment in the only other 
      periodic evaluation. With DSE in nine patients, a significant decrease in left 
      ventricular end-diastolic and end-systolic diameters (LVEDD and LVESD) as well as 
      LV end-diastolic and end-systolic volumes (LVEDV and LVESV) was documented in 
      comparison to resting values. EF and fractional shortening (FS) improved 
      significantly with DSE. Systolic wall stress (SWS) and pulmonary arterial 
      systolic pressure (PASP) did not change. Average follow-up was 6.7 months. Three 
      patients underwent valve replacement with mechanical prostheses. Two of them are 
      in NYHA Class I and the other died of LV failure 3 days after surgery. One 
      patient deteriorated beyond surgical treatment and was in NYHA Class II. The 
      other seven patients remain in NYHA Class II and await valve replacement. In 
      patients with chronic aortic regurgitation and depressed EF, the variables 
      relevant to myocardial reserve appear to be EF, FS, LVEDD, LVESD, LVEDV, and 
      LVESV.
FAU - Espinola-Zavaleta, N
AU  - Espinola-Zavaleta N
AD  - Department of Echocardiography, Instituto Nacional de Cardiologia Ignacio Chavez, 
      Juan Badiano No. 1, Colonia Seccion XVI, Tlalpan, Mexico, D.F., Mexico.
FAU - Gomez-Nunez, N
AU  - Gomez-Nunez N
FAU - Chavez, P Y
AU  - Chavez PY
FAU - Sahagun-Sanchez, G
AU  - Sahagun-Sanchez G
FAU - Keirns, C
AU  - Keirns C
FAU - Casanova, J M
AU  - Casanova JM
FAU - Romero-Cardenas, A
AU  - Romero-Cardenas A
FAU - Roldan, F J
AU  - Roldan FJ
FAU - Vargas-Barron, J
AU  - Vargas-Barron J
LA  - eng
PT  - Comparative Study
PT  - Evaluation Study
PT  - Journal Article
PL  - United States
TA  - Echocardiography
JT  - Echocardiography (Mount Kisco, N.Y.)
JID - 8511187
RN  - 3S12J47372 (Dobutamine)
SB  - IM
MH  - Adult
MH  - Aortic Valve Insufficiency/*diagnosis/diagnostic imaging
MH  - Chronic Disease
MH  - *Dobutamine
MH  - Echocardiography/methods
MH  - *Exercise Test
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Stroke Volume/drug effects/physiology
MH  - Ventricular Function, Left/drug effects/physiology
EDAT- 2001/09/25 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/25 10:00
PHST- 2001/09/25 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/25 10:00 [entrez]
AID - 10.1046/j.1540-8175.2001.00491.x [doi]
PST - ppublish
SO  - Echocardiography. 2001 Aug;18(6):491-6. doi: 10.1046/j.1540-8175.2001.00491.x.