PMID- 11568015
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20210216
IS  - 0006-4971 (Print)
IS  - 0006-4971 (Linking)
VI  - 98
IP  - 7
DP  - 2001 Oct 1
TI  - Translocations involving the immunoglobulin heavy-chain locus are possible early 
      genetic events in patients with primary systemic amyloidosis.
PG  - 2266-8
AB  - Primary systemic amyloidosis (AL) is a plasma cell (PC) dyscrasia with clinical 
      similarities to multiple myeloma (MM) and monoclonal gammopathy of undetermined 
      significance (MGUS), but its molecular basis is poorly understood. Translocations 
      at the immunoglobulin heavy-chain (IgH) locus, 14q32, are likely early genetic 
      events in both MM and MGUS and involve several nonrandom, recurrent, partner 
      chromosomes such as 11q13, 16q23, and 4p16.3. Given the similarities between MM, 
      MGUS, and AL, bone marrow clonal PCs were evaluated in 29 patients with AL using 
      interphase fluorescence in situ hybridization (FISH) combined with 
      immunofluorescence detection of the cytoplasmic light-chain (cIg-FISH) for the 
      presence of 14q32 translocations and the t(11;14)(q13;q32). Of 29 patients 
      studied, 21 (72.4%) showed results compatible with the presence of a 14q32 
      translocation, and 16 (76.2%) of those had translocation (11;14)(q13;q32) for an 
      overall prevalence of the abnormality of 55%. IgH translocations are common in 
      AL, especially the t(11;14)(q13;q32).
FAU - Hayman, S R
AU  - Hayman SR
AD  - Departments of Hematology and Internal Medicine and of Laboratory Medicine and 
      Pathology, Mayo Clinic, Rochester, MN 55905, USA.
FAU - Bailey, R J
AU  - Bailey RJ
FAU - Jalal, S M
AU  - Jalal SM
FAU - Ahmann, G J
AU  - Ahmann GJ
FAU - Dispenzieri, A
AU  - Dispenzieri A
FAU - Gertz, M A
AU  - Gertz MA
FAU - Greipp, P R
AU  - Greipp PR
FAU - Kyle, R A
AU  - Kyle RA
FAU - Lacy, M Q
AU  - Lacy MQ
FAU - Rajkumar, S V
AU  - Rajkumar SV
FAU - Witzig, T E
AU  - Witzig TE
FAU - Lust, J A
AU  - Lust JA
FAU - Fonseca, R
AU  - Fonseca R
LA  - eng
GR  - CA21115-25C/CA/NCI NIH HHS/United States
GR  - P01 CA62242/CA/NCI NIH HHS/United States
GR  - R01 CA83724-01/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Blood
JT  - Blood
JID - 7603509
RN  - 0 (Immunoglobulin Heavy Chains)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Amyloidosis/*genetics
MH  - Bone Marrow Cells/pathology
MH  - *Chromosomes, Human, Pair 11
MH  - *Chromosomes, Human, Pair 14
MH  - Female
MH  - Humans
MH  - Immunoglobulin Heavy Chains/*genetics
MH  - In Situ Hybridization, Fluorescence
MH  - Male
MH  - Middle Aged
MH  - Plasma Cells/pathology
MH  - Prevalence
MH  - Translocation, Genetic/*genetics
EDAT- 2001/09/25 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/25 10:00
PHST- 2001/09/25 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/25 10:00 [entrez]
AID - S0006-4971(20)58772-7 [pii]
AID - 10.1182/blood.v98.7.2266 [doi]
PST - ppublish
SO  - Blood. 2001 Oct 1;98(7):2266-8. doi: 10.1182/blood.v98.7.2266.