PMID- 11571024
OWN - NLM
STAT- MEDLINE
DCOM- 20011011
LR  - 20141120
IS  - 0955-3002 (Print)
IS  - 0955-3002 (Linking)
VI  - 77
IP  - 8
DP  - 2001 Aug
TI  - FISH examination of lymphocytes from Mayak workers for assessment of 
      translocation induction rate under chronic radiation exposures.
PG  - 901-8
AB  - PURPOSE: To estimate the translocation-induction rate under chronic exposure 
      conditions by measuring chromosome aberration frequencies in lymphocytes from 
      Mayak nuclear workers using fluorescence in situ hybridization (FISH). MATERIALS 
      AND METHODS: Lymphocytes were examined from 27 nuclear workers at the Mayak 
      Production Association and two control individuals using FISH with probes for 
      chromosomes 1, 2 and 4. Official doses derived from worker film-badge records 
      varied from 0 to 8.50 Gy. RESULTS: The mean (+/-SD) genome-equivalent 
      translocation frequency (F(G)) was 2.30 (+/-0.75)% in the zero-dose group (n = 
      7), and Poisson regression analysis provided the best-fit equation of F(G)(%) = 
      2.96(+/-0.39) + 0.69(+/-0.14)D + 0.12(+/-0.05)A, where D is the 
      film-badge-derived dose (Gy), and A is age centred at 67 years. The induction 
      rate would increase to nearly 1% Gy(-1) if the radiation dose to bone marrow, one 
      of the major organs for lymphocytes and where their precursor cells reside, is 
      considered. CONCLUSION: The estimated induction rate in vivo appeared 
      substantially smaller than linear coefficients estimated from various in vitro 
      studies.
FAU - Burak, L E
AU  - Burak LE
AD  - Clinical Department, Branch N1, Institute of Biophysics, Ozyorsk's shosse 19, 
      Ozyorsk, Chelyabinsk 456780, Russian Federation.
FAU - Kodama, Y
AU  - Kodama Y
FAU - Nakano, M
AU  - Nakano M
FAU - Ohtaki, K
AU  - Ohtaki K
FAU - Itoh, M
AU  - Itoh M
FAU - Okladnikova, N D
AU  - Okladnikova ND
FAU - Vasilenko, E K
AU  - Vasilenko EK
FAU - Cologne, J B
AU  - Cologne JB
FAU - Nakamura, N
AU  - Nakamura N
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Int J Radiat Biol
JT  - International journal of radiation biology
JID - 8809243
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Case-Control Studies
MH  - Dental Enamel/radiation effects
MH  - Dose-Response Relationship, Radiation
MH  - Electron Spin Resonance Spectroscopy
MH  - Female
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - In Vitro Techniques
MH  - Lymphocytes/radiation effects
MH  - Male
MH  - Middle Aged
MH  - *Occupational Exposure
MH  - *Power Plants
MH  - Russia
MH  - Time Factors
MH  - Translocation, Genetic/*radiation effects
EDAT- 2001/09/26 10:00
MHDA- 2001/10/12 10:01
CRDT- 2001/09/26 10:00
PHST- 2001/09/26 10:00 [pubmed]
PHST- 2001/10/12 10:01 [medline]
PHST- 2001/09/26 10:00 [entrez]
AID - 10.1080/09553000110063386 [doi]
PST - ppublish
SO  - Int J Radiat Biol. 2001 Aug;77(8):901-8. doi: 10.1080/09553000110063386.