PMID- 11571719
OWN - NLM
STAT- MEDLINE
DCOM- 20011004
LR  - 20220227
IS  - 0008-543X (Print)
IS  - 0008-543X (Linking)
VI  - 92
IP  - 5
DP  - 2001 Sep 1
TI  - Significant correlation of monocyte chemoattractant protein-1 expression with 
      neovascularization and progression of breast carcinoma.
PG  - 1085-91
AB  - BACKGROUND: Macrophages often infiltrate into solid tumor tissues. 
      Tumor-associated macrophages (TAMs) are known to play a crucial role in tumor 
      progression. Monocyte chemoattractant protein-1 (MCP-1) is one of the major 
      chemokines capable of inducing chemotactic migration of monocytes. METHODS: With 
      the objective of investigating the clinical significance of MCP-1, the authors 
      analyzed the expression of MCP-1 and of some other molecules by 
      immunohistochemistry in 230 samples of primary breast carcinoma tissue. MCP-1 
      staining was performed using an anti-MCP-1 monoclonal antibody, and it was 
      assessed by grading the percentage of stained cells. RESULTS: It was found that 
      117 breast tumor specimens (51%) had intensive staining in tumor cells. The 
      expression of MCP-1 in tumor cells had a significant correlation with the 
      expression of thymidine phosphorylase and membrane type 1-matrix 
      metalloproteinase. In addition, MCP-1 expression tended to be associated with the 
      accumulation of TAMs, which were counted by CD68 staining, and with microvessel 
      density. MCP-1 expression in TAMs was correlated significantly with the 
      histologic vessel invasion of tumor cells. CONCLUSIONS: The results of this study 
      suggest that MCP-1 may play key roles in macrophage recruitment, in the 
      expression of angiogenic factors, and in the activation of matrix 
      metalloproteinases in patients with breast carcinoma.
CI  - Copyright 2001 American Cancer Society.
FAU - Saji, H
AU  - Saji H
AD  - Department of Surgery, Breast Oncology Unit, Tokyo Metropolitan Komagome 
      Hospital, Tokyo, Japan.
FAU - Koike, M
AU  - Koike M
FAU - Yamori, T
AU  - Yamori T
FAU - Saji, S
AU  - Saji S
FAU - Seiki, M
AU  - Seiki M
FAU - Matsushima, K
AU  - Matsushima K
FAU - Toi, M
AU  - Toi M
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
RN  - 0 (Angiogenesis Inducing Agents)
RN  - 0 (Chemokine CCL2)
RN  - 0 (Receptors, Estrogen)
RN  - 0 (Receptors, Progesterone)
SB  - IM
MH  - Angiogenesis Inducing Agents
MH  - Breast Neoplasms/blood supply/*metabolism/pathology
MH  - Carcinoma/metabolism/pathology
MH  - Carcinoma, Ductal, Breast/blood supply/*metabolism/pathology
MH  - Chemokine CCL2/*metabolism
MH  - Humans
MH  - Immunohistochemistry
MH  - *Neovascularization, Pathologic/metabolism
MH  - Receptors, Estrogen/metabolism
MH  - Receptors, Progesterone/metabolism
MH  - Tumor Cells, Cultured
EDAT- 2001/09/26 10:00
MHDA- 2001/10/05 10:01
CRDT- 2001/09/26 10:00
PHST- 2001/09/26 10:00 [pubmed]
PHST- 2001/10/05 10:01 [medline]
PHST- 2001/09/26 10:00 [entrez]
AID - 10.1002/1097-0142(20010901)92:5<1085::AID-CNCR1424>3.0.CO;2-K [pii]
AID - 10.1002/1097-0142(20010901)92:5<1085::aid-cncr1424>3.0.co;2-k [doi]
PST - ppublish
SO  - Cancer. 2001 Sep 1;92(5):1085-91. doi: 
      10.1002/1097-0142(20010901)92:5<1085::aid-cncr1424>3.0.co;2-k.