PMID- 11572800
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190709
IS  - 0022-0795 (Print)
IS  - 0022-0795 (Linking)
VI  - 171
IP  - 1
DP  - 2001 Oct
TI  - Administration of bovine, porcine and equine growth hormone to the horse: effect 
      on insulin-like growth factor-I and selected IGF binding proteins.
PG  - 163-71
AB  - This study investigated the biochemical effects of administration of three types 
      of recombinant growth hormone (GH; somatotropin) to the Thoroughbred horse. 
      Equine or bovine or porcine GH was administered at a recommended dosage to 
      3-5-year old Thoroughbred geldings, for up to 21 days. It was shown that, in 
      addition to equine GH, bovine and porcine GH were active in the horse; however, 
      porcine GH caused injection-site reactions that were so serious that 
      administration had to be terminated. The concentrations of a range of GH-related 
      serum protein markers were determined before, during and after the administration 
      period. Because of the short half-life of GH itself, the objective was to 
      identify GH-related markers that showed changes in concentration and which could 
      be used as indicators of the abuse of these hormones. Among the possible markers 
      identified, serum total insulin-like growth factor (IGF)-I was shown to be the 
      most promising, increasing to 270% of the basal concentration for equine GH 
      administration. After GH administration, IGF-I took longer to attain baseline 
      concentrations than the time required for GH concentrations to recover to normal. 
      The concentration obtained from the administration significantly exceeded natural 
      concentrations for IGF-I, as was determined from a population of more than 2000 
      Thoroughbred horses in three continents. The concentrations of serum free IGF-I 
      and IGF binding protein 3 (IGFBP-3) were also shown to be significantly affected 
      by equine and bovine GH.
FAU - De Kock, S S
AU  - De Kock SS
AD  - The Laboratory of the Jockey Club of Southern Africa, PO Box 74439, Turffontein 
      2140, South Africa.
FAU - Rodgers, J P
AU  - Rodgers JP
FAU - Swanepoel, B C
AU  - Swanepoel BC
FAU - Guthrie, A J
AU  - Guthrie AJ
LA  - eng
PT  - Journal Article
PL  - England
TA  - J Endocrinol
JT  - The Journal of endocrinology
JID - 0375363
RN  - 0 (Biomarkers)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (Insulin-Like Growth Factor Binding Proteins)
RN  - 12629-01-5 (Human Growth Hormone)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
RN  - 9002-72-6 (Growth Hormone)
SB  - IM
MH  - Animals
MH  - Biomarkers/blood
MH  - Cattle
MH  - Growth Hormone/*pharmacology
MH  - Horses/*metabolism
MH  - Human Growth Hormone/pharmacology
MH  - Immunoradiometric Assay
MH  - Insulin-Like Growth Factor Binding Protein 3/blood
MH  - Insulin-Like Growth Factor Binding Proteins/blood/*metabolism
MH  - Insulin-Like Growth Factor I/analysis/*metabolism
MH  - Male
MH  - Orchiectomy
MH  - Random Allocation
MH  - Species Specificity
MH  - Swine
EDAT- 2001/09/27 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/27 10:00
PHST- 2001/09/27 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/27 10:00 [entrez]
AID - JOE04338 [pii]
AID - 10.1677/joe.0.1710163 [doi]
PST - ppublish
SO  - J Endocrinol. 2001 Oct;171(1):163-71. doi: 10.1677/joe.0.1710163.