PMID- 11574916
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20151119
IS  - 0022-1899 (Print)
IS  - 0022-1899 (Linking)
VI  - 184
IP  - 8
DP  - 2001 Oct 15
TI  - Increased macrophage chemoattractant protein-1 in cerebrospinal fluid precedes 
      and predicts simian immunodeficiency virus encephalitis.
PG  - 1015-21
AB  - Macrophage chemoattractant protein-1 (MCP-1) may be a key trigger for the influx 
      of macrophages into the brain in human immunodeficiency virus (HIV) encephalitis. 
      In this study, simian immunodeficiency virus-infected macaques that developed 
      moderate-to-severe encephalitis had significantly higher MCP-1 levels in 
      cerebrospinal fluid (CSF) than in plasma as early as 28 days after inoculation, 
      which was before the development of brain lesions. In contrast, CSF:plasma MCP-1 
      ratios remained constant at preinoculation levels in macaques that developed 
      minimal or no encephalitis. Abundant MCP-1 protein and mRNA were detected in both 
      macrophages and astrocytes in the brain. Macaques with increased MCP-1 in CSF had 
      significantly greater expression of markers of macrophage and microglia 
      activation and infiltration (CD68; P= .003) and astrocyte activation (glial 
      fibrillary acidic protein; P= .019 and P= .031 in white and gray matter, 
      respectively). The results suggest that the CSF:plasma MCP-1 ratio may be a 
      valuable prognostic marker for the development of HIV-induced central nervous 
      system disease.
FAU - Zink, M C
AU  - Zink MC
AD  - Division of Comparative Medicine, Department of Pathology, Johns Hopkins 
      University School of Medicine, Baltimore, Maryland 21287, USA. 
      m.czink@mail.jhmi.edu
FAU - Coleman, G D
AU  - Coleman GD
FAU - Mankowski, J L
AU  - Mankowski JL
FAU - Adams, R J
AU  - Adams RJ
FAU - Tarwater, P M
AU  - Tarwater PM
FAU - Fox, K
AU  - Fox K
FAU - Clements, J E
AU  - Clements JE
LA  - eng
GR  - MH-61187/MH/NIMH NIH HHS/United States
GR  - NS-35344/NS/NINDS NIH HHS/United States
GR  - NS-35751/NS/NINDS NIH HHS/United States
GR  - NS-36911/NS/NINDS NIH HHS/United States
GR  - RR-00116/RR/NCRR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
DEP - 20010910
PL  - United States
TA  - J Infect Dis
JT  - The Journal of infectious diseases
JID - 0413675
RN  - 0 (Chemokine CCL2)
SB  - IM
EIN - J Infect Dis 2002 Jun 1;185(11):1696
MH  - Animals
MH  - Brain/pathology
MH  - Brain Chemistry
MH  - Chemokine CCL2/blood/*cerebrospinal fluid/genetics
MH  - Disease Models, Animal
MH  - Encephalitis, Viral/*diagnosis
MH  - Humans
MH  - Immunohistochemistry
MH  - Macaca
MH  - Predictive Value of Tests
MH  - Simian Acquired Immunodeficiency Syndrome/*cerebrospinal 
      fluid/complications/pathology
MH  - *Simian Immunodeficiency Virus
EDAT- 2001/09/28 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/28 10:00
PHST- 2001/04/19 00:00 [received]
PHST- 2001/06/19 00:00 [revised]
PHST- 2001/09/28 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/28 10:00 [entrez]
AID - JID010447 [pii]
AID - 10.1086/323478 [doi]
PST - ppublish
SO  - J Infect Dis. 2001 Oct 15;184(8):1015-21. doi: 10.1086/323478. Epub 2001 Sep 10.