PMID- 11576182
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190815
IS  - 0953-816X (Print)
IS  - 0953-816X (Linking)
VI  - 14
IP  - 5
DP  - 2001 Sep
TI  - Development of brain-derived neurotrophic factor and neurotrophin-3 
      immunoreactivity in the lower auditory brainstem of the postnatal gerbil.
PG  - 785-93
AB  - The localization of brain-derived neurotrophic factor (BDNF) and neurotrophin-3 
      (NT-3) in the gerbil auditory brainstem was studied during normal postnatal 
      development. The principal objective of this paper was to compare the 
      developmental distribution of BDNF and NT-3 proteins to the known developmental 
      distribution of their cognate, high-affinity tyrosine kinase receptors. BDNF and 
      NT-3 proteins were localized using standard immunohistochemistry. No specific 
      immunoreactivity for BDNF or NT-3 was detected on the day of birth (P0) in any 
      auditory structure, although fibers comprising the spinal tract of the Vth 
      cranial nerve were well labelled with antibodies against BDNF. Diffuse 
      immunoreactivity for both BDNF and NT-3 was first detected at P3 in the cochlear 
      nucleus and in several second order auditory nuclei in the superior olivary 
      complex. This diffuse immunoreactivity became clustered and restricted to 
      neuronal cell bodies by P10. Immunoreactivity for both BDNF and NT-3 transiently 
      disappeared in the lateral and medial superior olivary nuclei at P10. However, 
      neurons in the medial nucleus of the trapezoid body remained immunopositive for 
      both BDNF and NT-3. Fibers in the trapezoid body were labelled with BDNF 
      immunoreactivity by P12. Between P12 and P15, the distribution of BDNF and NT-3 
      immunoreactivity in the cochlear nucleus and superior olivary complex became 
      comparable to adult (P140) immunolabel. These results show that the normal 
      developmental distribution of the neurotrophins BDNF and NT-3 in the lower 
      auditory brainstem occurs during the first two postnatal weeks in parallel with 
      the developmental expression of their cognate receptors, trkB and trkC.
FAU - Tierney, T S
AU  - Tierney TS
AD  - University Laboratory of Physiology, Parks Road, Oxford OX1 3PT, UK.
FAU - P Doubell, T
AU  - P Doubell T
FAU - Xia, G
AU  - Xia G
FAU - Moore, D R
AU  - Moore DR
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - France
TA  - Eur J Neurosci
JT  - The European journal of neuroscience
JID - 8918110
RN  - 0 (Antibodies)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Neurotrophin 3)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 2.7.10.1 (Receptor, trkC)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Antibodies
MH  - Auditory Pathways/chemistry/growth & development
MH  - Brain-Derived Neurotrophic Factor/*analysis/immunology
MH  - Cochlear Nucleus/*chemistry/*growth & development
MH  - Gerbillinae
MH  - Immunohistochemistry
MH  - Neurotrophin 3/*analysis/immunology
MH  - Olivary Nucleus/chemistry/growth & development
MH  - Receptor, trkB/analysis/immunology
MH  - Receptor, trkC/analysis/immunology
EDAT- 2001/09/29 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/09/29 10:00
PHST- 2001/09/29 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/29 10:00 [entrez]
AID - ejn1690 [pii]
AID - 10.1046/j.0953-816x.2001.01690.x [doi]
PST - ppublish
SO  - Eur J Neurosci. 2001 Sep;14(5):785-93. doi: 10.1046/j.0953-816x.2001.01690.x.