PMID- 11577130
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190501
IS  - 0021-9746 (Print)
IS  - 1472-4146 (Electronic)
IS  - 0021-9746 (Linking)
VI  - 54
IP  - 10
DP  - 2001 Oct
TI  - Fatal acute myocarditis in an infant with human herpesvirus 6 infection.
PG  - 792-5
AB  - A 5 month old girl had typical clinical features of acute myocarditis just after 
      the febrile period of exanthem subitum and died immediately. She had been 
      healthy, with normal development, and there was no family history of particular 
      note. Myocardial postmortem findings were compatible with acute myocarditis. 
      Although the isolation of human herpesvirus 6 (HHV-6) was not attempted, positive 
      IgM antibody to HHV-6 was detected in the patient's serum. Moreover, HHV-6 
      variant B DNA was detected in several tissues, including myocardium, by the 
      polymerase chain reaction (PCR). In contrast, antibody responses to human 
      herpesvirus 7, another causal agent of exanthem subitum, were not found, and 
      enteroviral RNA was not detected in myocardial tissues by reverse transcription 
      PCR. Apoptotic changes were seen in infiltrating cells within the myocardial 
      tissues by means of the TUNEL method. HHV-6 antigen was not detected in several 
      tissues (including myocardium) by immunohistochemical analysis. In conclusion, 
      HHV-6 may have been the causative agent of fatal acute myocarditis in this 
      infant.
FAU - Yoshikawa, T
AU  - Yoshikawa T
AD  - Department of Pediatrics, Fujita Health University School of Medicine, Toyoake, 
      Aichi, Japan. tetsushi@med.nagoya-u.ac.jp
FAU - Ihira, M
AU  - Ihira M
FAU - Suzuki, K
AU  - Suzuki K
FAU - Suga, S
AU  - Suga S
FAU - Kito, H
AU  - Kito H
FAU - Iwasaki, T
AU  - Iwasaki T
FAU - Kurata, T
AU  - Kurata T
FAU - Tanaka, T
AU  - Tanaka T
FAU - Saito, Y
AU  - Saito Y
FAU - Asano, Y
AU  - Asano Y
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - England
TA  - J Clin Pathol
JT  - Journal of clinical pathology
JID - 0376601
RN  - 0 (Antibodies, Viral)
RN  - 0 (DNA, Viral)
RN  - 0 (Immunoglobulin M)
SB  - IM
MH  - Acute Disease
MH  - Antibodies, Viral/immunology
MH  - DNA, Viral/analysis
MH  - Exanthema Subitum/*virology
MH  - Fatal Outcome
MH  - Female
MH  - Herpesvirus 6, Human/*genetics
MH  - Humans
MH  - Immunoglobulin M/immunology
MH  - In Situ Nick-End Labeling
MH  - Infant
MH  - Myocarditis/*virology
MH  - Polymerase Chain Reaction/methods
PMC - PMC1731282
EDAT- 2001/09/29 10:00
MHDA- 2002/01/05 10:01
PMCR- 2004/10/01
CRDT- 2001/09/29 10:00
PHST- 2001/09/29 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/09/29 10:00 [entrez]
PHST- 2004/10/01 00:00 [pmc-release]
AID - 10.1136/jcp.54.10.792 [doi]
PST - ppublish
SO  - J Clin Pathol. 2001 Oct;54(10):792-5. doi: 10.1136/jcp.54.10.792.