PMID- 11577998
OWN - NLM
STAT- MEDLINE
DCOM- 20020412
LR  - 20181113
IS  - 0962-9351 (Print)
IS  - 0962-9351 (Linking)
VI  - 10
IP  - 4
DP  - 2001 Aug
TI  - Analysis of IgE turnover in non-sensitized and sensitized rats.
PG  - 217-21
AB  - BACKGROUND: Although the levels of immunoglobulin E (IgE) in the circulating 
      blood are often elevated in patients with allergic diseases, such levels cannot 
      always be considered as pathognomonic signs of allergy. The induction of allergic 
      reactions in the tissue was inferred to be related to the amount of IgE passing 
      through the vascular wall. AIMS: We attempted to clarify which compartment, the 
      intravascular or extravascular, plays an important role in the regulation of the 
      turnover of rat IgE. METHODS: The level of DNP-specific rat IgE in the serum was 
      estimated by IgE-capture enzyme-linked immunosorbent assay, and the turnover of 
      IgE was analyzed from its pharmacokinetic parameters. RESULTS: The transfer rate 
      constants from the central to tissue compartment (Kct) were larger than those 
      from the tissue to central compartment (Ktc) irrespective of the sensitized 
      state. The value of the distribution volume of the tissue compartment (Vt) was 
      larger than that of the distribution volume of the central compartment (Vc) 
      irrespective of the sensitized state. CONCLUSIONS: These Findings suggest that 
      the short half-life of rat IgE in the circulation could be attributable to the 
      distribution of IgE from the intravascular to the extravascular compartment.
FAU - Hanashiro, K
AU  - Hanashiro K
AD  - 1st Department of Physiology, School of Medicine, University of the Ryukyus, 
      Nishihara, Okinawa, Japan. tkosugi@med.u-ryukyu.ac.jp
FAU - Tokeshi, Y
AU  - Tokeshi Y
FAU - Nakasone, T
AU  - Nakasone T
FAU - Sunagawa, M
AU  - Sunagawa M
FAU - Nakamura, M
AU  - Nakamura M
FAU - Kosugi, T
AU  - Kosugi T
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Mediators Inflamm
JT  - Mediators of inflammation
JID - 9209001
RN  - 0 (Antibodies, Monoclonal)
RN  - 0 (Benzenesulfonates)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 3WF0U675G6 (2,4-dinitrobenzenesulfonic acid)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Animals
MH  - Antibodies, Monoclonal/blood
MH  - Benzenesulfonates/immunology
MH  - Body Fluid Compartments
MH  - Dose-Response Relationship, Immunologic
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Humans
MH  - Hypersensitivity/*immunology
MH  - Immunoglobulin E/*blood/immunology/metabolism
MH  - Male
MH  - Ovalbumin/immunology
MH  - Rats
MH  - Rats, Wistar
PMC - PMC1781713
EDAT- 2001/10/02 10:00
MHDA- 2002/04/16 10:01
PMCR- 2001/08/01
CRDT- 2001/10/02 10:00
PHST- 2001/10/02 10:00 [pubmed]
PHST- 2002/04/16 10:01 [medline]
PHST- 2001/10/02 10:00 [entrez]
PHST- 2001/08/01 00:00 [pmc-release]
AID - 10.1080/09629350123338 [doi]
PST - ppublish
SO  - Mediators Inflamm. 2001 Aug;10(4):217-21. doi: 10.1080/09629350123338.