PMID- 11578189
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20190814
IS  - 0020-1669 (Print)
IS  - 0020-1669 (Linking)
VI  - 40
IP  - 21
DP  - 2001 Oct 8
TI  - Use of SDS micelles to stabilize a ternary intermediate in the reaction of 
      ferrioxamine B and 1,10-phenanthroline.
PG  - 5420-7
AB  - Spectrophotometric measurements of the reaction of ferrioxamine B (FeHDFB(+)) 
      with 1,10-phenanthroline (phen) reveal the presence of a ternary intermediate 
      complex in both aqueous solution and an aqueous solution of 0.16 M sodium dodecyl 
      sulfate (SDS). The stoichiometry of the intermediate is Fe(H(2)DFB)(phen)(2+) on 
      the basis of a Schwarzenbach analysis of spectrophotometric data obtained at 
      variable pH and phen concentrations. The ternary complex formation constant for 
      the reaction FeHDFB(+) + H(+) + phen right arrow over left arrow 
      Fe(H(2)DFB)(phen)(2+) is log K = 6.96 in aqueous solution and log K = 8.64 in 
      aqueous 0.16 M SDS. The enhanced stability of Fe(H(2)DFB)(phen)(2+) in micellar 
      solution was analyzed in terms of the pseudophase ion-exchange (PPIE) model of 
      micellar reactions. The association constants for the binding of each reactant to 
      the micellar pseudophase were measured by ultrafiltration. According to PPIE 
      model calculations, the enhanced stability of Fe(H(2)DFB)(phen)(2+) in micellar 
      SDS arises from a proximity effect created by the high local concentrations of 
      reactants in the micellar pseudophase. The calculations also indicate that an 
      inhibitory medium or compartmentalization effect is operative since the observed 
      micellar enhancement is much smaller than predicted by the PPIE model. The 
      micellar stabilization of the Fe(H(2)DFB)(phen)(2+) intermediate and the overall 
      conversion of FeHDFB(+) to Fe(phen)(3)(2+) are discussed as a possible model 
      system for siderophore iron release in microbial organisms.
FAU - Olmstead, E G Jr
AU  - Olmstead EG Jr
AD  - Department of Chemistry, Duke University, Box 90346, Durham, North Carolina 
      27708-0346, USA.
FAU - Harman, S W
AU  - Harman SW
FAU - Choo, P L
AU  - Choo PL
FAU - Crumbliss, A L
AU  - Crumbliss AL
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, Non-P.H.S.
PL  - United States
TA  - Inorg Chem
JT  - Inorganic chemistry
JID - 0366543
RN  - 0 (Ferric Compounds)
RN  - 0 (Micelles)
RN  - 0 (Phenanthrolines)
RN  - 0 (Siderophores)
RN  - 059QF0KO0R (Water)
RN  - 368GB5141J (Sodium Dodecyl Sulfate)
RN  - 4A0UG9NR9K (ferrioxamine B)
RN  - E1UOL152H7 (Iron)
RN  - J06Y7MXW4D (Deferoxamine)
RN  - W4X6ZO7939 (1,10-phenanthroline)
SB  - IM
MH  - Cell Membrane/metabolism
MH  - Deferoxamine/*chemistry
MH  - Ferric Compounds/*chemistry
MH  - Iron/metabolism
MH  - Kinetics
MH  - *Micelles
MH  - Molecular Mimicry
MH  - Phenanthrolines/*chemistry
MH  - Siderophores/metabolism
MH  - Sodium Dodecyl Sulfate/*chemistry
MH  - Water/chemistry
EDAT- 2001/10/02 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/02 10:00
PHST- 2001/10/02 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/02 10:00 [entrez]
AID - ic0008621 [pii]
AID - 10.1021/ic0008621 [doi]
PST - ppublish
SO  - Inorg Chem. 2001 Oct 8;40(21):5420-7. doi: 10.1021/ic0008621.