PMID- 11578300
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20061115
IS  - 0007-1323 (Print)
IS  - 0007-1323 (Linking)
VI  - 88
IP  - 10
DP  - 2001 Oct
TI  - Prospective controlled trial of a standardized meal stimulation test in the 
      detection of pancreaticoduodenal endocrine tumours in patients with multiple 
      endocrine neoplasia type 1.
PG  - 1403-7
AB  - BACKGROUND: Use of a standardized meal stimulation test has been recommended for 
      the early diagnosis of pancreaticoduodenal endocrine tumours (PETs) in patients 
      with multiple endocrine neoplasia type 1 (MEN 1). The diagnostic value of this 
      test was re-evaluated. METHODS: In a prospective, controlled trial 58 
      standardized meal stimulation tests (563 kcal) were performed in 12 patients with 
      MEN 1 and histologically, biochemically and/or radiologically confirmed PETs 
      (group 1), 11 carriers of an MEN 1 mutation with no evidence of PETs (group 2) 
      and in 27 healthy controls (group 3). Serum pancreatic polypeptide (PP) and 
      gastrin concentrations were measured before and during the test meal. RESULTS: 
      Patients in group 1 had significantly higher mean basal serum PP and gastrin 
      concentrations than patients in group 2 and controls (P < 0.05). In all three 
      groups an increase in serum PP was observed after meal stimulation, but there was 
      no significant difference between the groups. No increase in gastrin level was 
      found in any of the groups after meal stimulation. CONCLUSION: The standardized 
      meal stimulation test does not reliably indicate the presence of PETs in patients 
      with MEN 1, whereas raised basal serum PP and gastrin levels do. The expensive 
      and time-consuming meal test can be excluded from MEN 1 screening programmes.
FAU - Langer, P
AU  - Langer P
AD  - Department of General Surgery, Philipps-University, Marburg, Germany.
FAU - Wild, A
AU  - Wild A
FAU - Celik, I
AU  - Celik I
FAU - Kopp, I
AU  - Kopp I
FAU - Bergenfelz, A
AU  - Bergenfelz A
FAU - Bartsch, D K
AU  - Bartsch DK
LA  - eng
PT  - Clinical Trial
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Br J Surg
JT  - The British journal of surgery
JID - 0372553
RN  - 0 (Gastrins)
RN  - 59763-91-6 (Pancreatic Polypeptide)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Duodenal Neoplasms/*blood/diagnosis/genetics
MH  - Female
MH  - Gastrins/blood
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Multiple Endocrine Neoplasia Type 1/*blood/complications/genetics
MH  - Mutation/genetics
MH  - Pancreatic Neoplasms/*blood/diagnosis/genetics
MH  - Pancreatic Polypeptide/blood
MH  - Prospective Studies
EDAT- 2001/10/02 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/10/02 10:00
PHST- 2001/10/02 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/10/02 10:00 [entrez]
AID - bjs1874 [pii]
AID - 10.1046/j.0007-1323.2001.01874.x [doi]
PST - ppublish
SO  - Br J Surg. 2001 Oct;88(10):1403-7. doi: 10.1046/j.0007-1323.2001.01874.x.