PMID- 11578684 OWN - NLM STAT- MEDLINE DCOM- 20011226 LR - 20190826 IS - 0165-2478 (Print) IS - 0165-2478 (Linking) VI - 78 IP - 3 DP - 2001 Oct 1 TI - Dendritic cells: their significance in health and disease. PG - 113-22 AB - Dendritic cells (DCs) represent a heterogeneous population of professional antigen-presenting cells. Precursor cells move via the blood to peripheral tissues. These immature DCs can take up invading pathogens and then rapidly migrate to the draining secondary lymphoid organs. Converted into antigen-presenting mature DCs, these cells are able to prime naive T cells and to initiate an adoptive immune response. The extraordinary functional profile suggests that, under certain preconditions, DCs may represent an ideal vector in the immunotherapy of cancer and infectious diseases FAU - Keller, R AU - Keller R AD - Department of Pathology, Institute of Experimental Immunology, University of Zurich, CH-8091, Zurich, Switzerland. LA - eng PT - Journal Article PT - Review PL - Netherlands TA - Immunol Lett JT - Immunology letters JID - 7910006 SB - IM MH - Animals MH - Antigen-Presenting Cells/immunology/pathology MH - Autoimmune Diseases/pathology MH - Dendritic Cells/*immunology/*pathology MH - Humans MH - Hypersensitivity/pathology MH - Tissue Distribution/immunology/physiology RF - 108 EDAT- 2001/10/02 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/10/02 10:00 PHST- 2001/10/02 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/10/02 10:00 [entrez] AID - S0165247801002474 [pii] AID - 10.1016/s0165-2478(01)00247-4 [doi] PST - ppublish SO - Immunol Lett. 2001 Oct 1;78(3):113-22. doi: 10.1016/s0165-2478(01)00247-4.