PMID- 11579199
OWN - NLM
STAT- MEDLINE
DCOM- 20020221
LR  - 20051116
IS  - 0888-8809 (Print)
IS  - 0888-8809 (Linking)
VI  - 15
IP  - 10
DP  - 2001 Oct
TI  - Molecular and genetic mechanisms of tumorigenesis in multiple endocrine neoplasia 
      type-1.
PG  - 1653-64
AB  - Multiple endocrine neoplasia type 1 (MEN1) is a rare but informative syndrome for 
      endocrine tumorigenesis. Since its isolation, several groups have begun to 
      determine the role of menin, the protein product of MEN1, in sporadic endocrine 
      tumors as well as tumors of the MEN1 syndrome. Mutations of menin have been 
      reported in more than 400 families and tumors, most of which are truncating 
      mutations, thus supporting the function of menin as a tumor suppressor. The exact 
      function of menin is unknown, but overexpression of menin inhibits proliferation 
      of Ras-transformed NIH3T3 cells. Since menin interacts with proteins from both 
      the TGF beta and AP-1 signaling pathways, perhaps its tumor suppressor function 
      is related to these key cell growth pathways. In this review we will discuss the 
      various clinical manifestations of MEN1 syndrome, potential mechanisms of MEN1 
      tumorigenesis, and mutations associated with MEN and sporadic endocrine tumors.
FAU - Guo, S S
AU  - Guo SS
AD  - Department of Surgery, West Los Angeles Veterans Affairs Medical Center and the 
      University of California Los Angeles School of Medicine, Los Angeles, California 
      90073, USA.
FAU - Sawicki, M P
AU  - Sawicki MP
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Mol Endocrinol
JT  - Molecular endocrinology (Baltimore, Md.)
JID - 8801431
RN  - 0 (MEN1 protein, human)
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Proto-Oncogene Proteins)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Gene Expression
MH  - Humans
MH  - Molecular Sequence Data
MH  - Multiple Endocrine Neoplasia Type 1/diagnosis/*genetics
MH  - Mutation
MH  - Neoplasm Proteins/chemistry/genetics
MH  - *Proto-Oncogene Proteins
MH  - Sequence Alignment
RF  - 131
EDAT- 2001/10/02 10:00
MHDA- 2002/02/22 10:01
CRDT- 2001/10/02 10:00
PHST- 2001/10/02 10:00 [pubmed]
PHST- 2002/02/22 10:01 [medline]
PHST- 2001/10/02 10:00 [entrez]
AID - 10.1210/mend.15.10.0717 [doi]
PST - ppublish
SO  - Mol Endocrinol. 2001 Oct;15(10):1653-64. doi: 10.1210/mend.15.10.0717.