PMID- 11580922
OWN - NLM
STAT- MEDLINE
DCOM- 20020219
LR  - 20190706
IS  - 0009-8981 (Print)
IS  - 0009-8981 (Linking)
VI  - 312
IP  - 1-2
DP  - 2001 Oct
TI  - Acanthopanax senticosus root inhibits mast cell-dependent anaphylaxis.
PG  - 163-8
AB  - BACKGROUND: Mast cells synthesize and secrete chemical mediators which play a 
      central role in anaphylaxis. METHODS: The effect of Acanthopanax senticosus root 
      (ASR) on mast cell-dependent anaphylaxis was investigated. RESULTS: ASR inhibited 
      compound 48/80-induced systemic anaphylactic shock at the dose of 1.0 g/kg by 
      50%. When ASR was given as pre-treatment at concentrations ranging from 0.01 to 
      2.0 g/l, the histamine release from rat peritoneal mast cells induced by compound 
      48/80 was reduced in a dose-dependent manner. ASR (2.0 g/kg) also inhibited 
      passive cutaneous anaphylaxis activated by anti-dinitrophenyl (DNP) IgE to 
      53.17+/-6.62%. Moreover, ASR inhibited tumor necrosis factor-alpha production in 
      a concentration-dependent manner, and the treatment of 1 g/l blocked the 
      production by 32.5+/-3.50% compared to saline value. CONCLUSIONS: ASR may possess 
      effective anti-anaphylactic activity.
FAU - Yi, J M
AU  - Yi JM
AD  - Department of Oriental Pharmacy, College of Pharmacy and Center of Oriental 
      Medicinal Science, Wonkwang University, Chonbuk, 570-749, Iksan City, South 
      Korea.
FAU - Kim, M S
AU  - Kim MS
FAU - Seo, S W
AU  - Seo SW
FAU - Lee, K N
AU  - Lee KN
FAU - Yook, C S
AU  - Yook CS
FAU - Kim, H M
AU  - Kim HM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Clin Chim Acta
JT  - Clinica chimica acta; international journal of clinical chemistry
JID - 1302422
RN  - 0 (Dinitrobenzenes)
RN  - 0 (Plant Extracts)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - 37341-29-0 (Immunoglobulin E)
RN  - 4091-50-3 (p-Methoxy-N-methylphenethylamine)
RN  - 820484N8I3 (Histamine)
SB  - IM
MH  - Anaphylaxis/chemically induced/*drug therapy/pathology
MH  - Animals
MH  - Cells, Cultured
MH  - Dinitrobenzenes/immunology
MH  - Histamine/metabolism
MH  - Immunoglobulin E/pharmacology
MH  - Male
MH  - Mast Cells/*drug effects/metabolism
MH  - Mice
MH  - Mice, Inbred ICR
MH  - Plant Extracts/*pharmacology
MH  - Plant Roots/chemistry
MH  - Plants, Medicinal
MH  - Rats
MH  - Rats, Sprague-Dawley
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - p-Methoxy-N-methylphenethylamine/adverse effects
EDAT- 2001/10/03 10:00
MHDA- 2002/02/20 10:01
CRDT- 2001/10/03 10:00
PHST- 2001/10/03 10:00 [pubmed]
PHST- 2002/02/20 10:01 [medline]
PHST- 2001/10/03 10:00 [entrez]
AID - S0009898101006131 [pii]
AID - 10.1016/s0009-8981(01)00613-1 [doi]
PST - ppublish
SO  - Clin Chim Acta. 2001 Oct;312(1-2):163-8. doi: 10.1016/s0009-8981(01)00613-1.