PMID- 11583919
OWN - NLM
STAT- MEDLINE
DCOM- 20020115
LR  - 20190921
IS  - 0898-6568 (Print)
IS  - 0898-6568 (Linking)
VI  - 13
IP  - 11
DP  - 2001 Nov
TI  - MafG-2 is a novel Maf protein that is expressed by stimulation of extracellular 
      H(+).
PG  - 835-9
AB  - We cloned MafG-2, a novel splice variant of MafG, from rat brain by RT-PCR 
      method. MafG-2 differs from the previously published MafG by an insertion of 27 
      amino acids. Sequence analysis of the cDNA-encoded MafG-2 showed that MafG-2 
      contains basic domain and basic leucine zipper (bZip) motif. Transient 
      transfection studies with GFP-MafG-2 chimera protein indicate that MafG-2 is 
      localized in the nuclei of transfected COS-7 cells. To determine whether gene 
      expression of mafG-2 mRNA is induced by an increase in extracellular protons, we 
      analyzed expression of the mRNA in PC12 cells after an increase in extracellular 
      proton concentration. We found that the mafG-2 mRNA expression increased when 
      extracellular pH was decreased gradually from 7.40 to 7.20 and that there was a 
      significant correlation between extracellular pH value and the expression of 
      mafG-2 mRNA. These results suggest that an increase in extracellular proton may 
      induce the expression of mafG-2 mRNA and MafG-2 may be involved in signal 
      transduction of extracellular of H(+).
FAU - Shimokawa, N
AU  - Shimokawa N
AD  - Physiology 1st Division, Gunma University School of Medicine, 3-39-22 
      Showa-machi, 371-8511, Maebashi, Japan.
FAU - Kumaki, I
AU  - Kumaki I
FAU - Takayama, K
AU  - Takayama K
LA  - eng
SI  - GENBANK/AB050011
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Cell Signal
JT  - Cellular signalling
JID - 8904683
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (MafG Transcription Factor)
RN  - 0 (Mafg protein, mouse)
RN  - 0 (Mafg protein, rat)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Protons)
RN  - 0 (RNA, Messenger)
RN  - 0 (Repressor Proteins)
RN  - 0 (Transcription Factors)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Base Sequence
MH  - COS Cells
MH  - Cloning, Molecular
MH  - DNA-Binding Proteins/biosynthesis/*genetics
MH  - Extracellular Space/physiology
MH  - Hydrogen-Ion Concentration
MH  - MafG Transcription Factor
MH  - Mice
MH  - Molecular Sequence Data
MH  - Nuclear Proteins/biosynthesis/*genetics
MH  - PC12 Cells
MH  - Phylogeny
MH  - *Protons
MH  - RNA, Messenger/biosynthesis
MH  - Rats
MH  - Repressor Proteins/biosynthesis/*genetics
MH  - Sequence Homology, Amino Acid
MH  - Transcription Factors/biosynthesis/*genetics
MH  - *Transcriptional Activation
EDAT- 2001/10/05 10:00
MHDA- 2002/01/16 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/01/16 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - S0898-6568(01)00213-3 [pii]
AID - 10.1016/s0898-6568(01)00213-3 [doi]
PST - ppublish
SO  - Cell Signal. 2001 Nov;13(11):835-9. doi: 10.1016/s0898-6568(01)00213-3.