PMID- 11584168
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20191025
IS  - 0268-4705 (Print)
IS  - 0268-4705 (Linking)
VI  - 16
IP  - 5
DP  - 2001 Sep
TI  - Adjunctive pharmacotherapy for coronary stenting.
PG  - 293-9
AB  - The use of coronary stents improves the outcomes of percutaneous coronary 
      intervention (PCI). This has led to a rapid increase in their use. Coronary 
      stenting is not without problems and is complicated by both early ischemic events 
      and late restenosis. The combination of anticoagulation with unfractionated 
      heparin (UFH) and the use of antiplatelet agents including aspirin, 
      thienopyridines, and glycoprotein IIb/IIIa inhibitors has led to a major 
      reduction in early ischemic events after stenting. Low molecular weight heparin 
      (LMWH) and direct thrombin inhibitors have a number of theoretical advantages 
      over UFH. Their role as an adjunct to coronary stenting is still under 
      investigation. Trials of systemic pharmacotherapy aimed at reducing in-stent 
      restenosis have been consistently disappointing. Preliminary results of stents 
      coated with agents that inhibit neointimal proliferation are extremely promising. 
      The results of ongoing phase III trials of these coated stents are eagerly 
      awaited.
FAU - Harding, S A
AU  - Harding SA
AD  - Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts 
      02114, USA.
FAU - Walters, D L
AU  - Walters DL
FAU - Palacios, I F
AU  - Palacios IF
FAU - Oesterle, S N
AU  - Oesterle SN
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - Curr Opin Cardiol
JT  - Current opinion in cardiology
JID - 8608087
RN  - 0 (Platelet Aggregation Inhibitors)
SB  - IM
MH  - Coronary Disease/*drug therapy/*surgery
MH  - Humans
MH  - Platelet Aggregation Inhibitors/therapeutic use
MH  - *Stents
RF  - 76
EDAT- 2001/10/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - 10.1097/00001573-200109000-00007 [doi]
PST - ppublish
SO  - Curr Opin Cardiol. 2001 Sep;16(5):293-9. doi: 10.1097/00001573-200109000-00007.