PMID- 11584364
OWN - NLM
STAT- MEDLINE
DCOM- 20011018
LR  - 20220331
IS  - 0270-9139 (Print)
IS  - 1527-3350 (Electronic)
IS  - 0270-9139 (Linking)
VI  - 34
IP  - 4 Pt 1
DP  - 2001 Oct
TI  - The processing and utilization of hepatocyte growth factor/scatter factor 
      following partial hepatectomy in the rat.
PG  - 688-93
AB  - Hepatocyte growth factor/scatter factor (HGF/SF) is a pluripotent growth factor 
      capable of acting as a motogen, a morphogen, and a mitogen. Originally, HGF/SF 
      was found as a blood-borne mitogen for hepatocytes and has since been determined 
      to be very important in liver repair. Previous studies have established that 
      HGF/SF must be proteolytically cleaved to elicit its effects. After liver injury 
      by toxins such as carbon tetrachloride or after surgical resection, partial 
      hepatectomy (PHX), HGF/SF concentrations increase in the blood. The aims of this 
      study were to examine (1) which form of HGF/SF is present in the normal liver, 
      (2) which form is present in the regenerating liver after PHX, and (3) if the 
      HGF/SF used after PHX is derived from existing liver reservoirs. Both 
      single-chain HGF/SF and active two-chain HGF/SF are present in normal liver, with 
      the former being the dominant form. After PHX, the liver can be described as 
      having two phases with regard to the use of endogenous HGF/SF. The first phase 
      from 0 to 3 hours is the consumptive phase and is characterized by a decrease in 
      both single-chain HGF/SF and active two-chain HGF/SF. The second phase is the 
      productive phase. It is characterized by a pronounced reappearance of both 
      single-chain HGF/SF as well as two-chain HGF/SF. The activation index shows a 
      5-fold increase over sham operations during the productive phase. The use of 
      radiolabeled HGF/SF showed that during the first 3 hours, HGF/SF is used in part 
      from hepatic stores. Furthermore, during the first 3 hours after PHX, only active 
      two-chain HGF/SF is seen in the plasma.
FAU - Pediaditakis, P
AU  - Pediaditakis P
AD  - Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, 
      PA 15261, USA.
FAU - Lopez-Talavera, J C
AU  - Lopez-Talavera JC
FAU - Petersen, B
AU  - Petersen B
FAU - Monga, S P
AU  - Monga SP
FAU - Michalopoulos, G K
AU  - Michalopoulos GK
LA  - eng
GR  - R01 CA035373/CA/NCI NIH HHS/United States
GR  - CA30241/CA/NCI NIH HHS/United States
GR  - CA35373/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - United States
TA  - Hepatology
JT  - Hepatology (Baltimore, Md.)
JID - 8302946
RN  - 0 (RNA, Messenger)
RN  - 67256-21-7 (Hepatocyte Growth Factor)
RN  - 9007-49-2 (DNA)
SB  - IM
MH  - Animals
MH  - DNA/biosynthesis
MH  - *Hepatectomy
MH  - Hepatocyte Growth Factor/genetics/*metabolism
MH  - Liver Regeneration
MH  - Male
MH  - RNA, Messenger/analysis
MH  - Rats
MH  - Rats, Inbred F344
PMC - PMC1821089
MID - NIHMS16108
EDAT- 2001/10/05 10:00
MHDA- 2001/10/19 10:01
PMCR- 2008/02/01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2001/10/19 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
PHST- 2008/02/01 00:00 [pmc-release]
AID - S0270-9139(01)35210-2 [pii]
AID - 10.1053/jhep.2001.27811 [doi]
PST - ppublish
SO  - Hepatology. 2001 Oct;34(4 Pt 1):688-93. doi: 10.1053/jhep.2001.27811.