PMID- 11584927
OWN - NLM
STAT- MEDLINE
DCOM- 20020204
LR  - 20220309
IS  - 0735-7044 (Print)
IS  - 0735-7044 (Linking)
VI  - 115
IP  - 5
DP  - 2001 Oct
TI  - Performance of heterozygous brain-derived neurotrophic factor knockout mice on 
      behavioral analogues of anxiety, nociception, and depression.
PG  - 1145-53
AB  - Evidence suggests that brain-derived neurotrophic factor (BDNF) may be important 
      in the pathophysiology of depression, in addition to its role as a neurotrophic 
      factor for sensory neurons. The authors conducted a series of experiments 
      examining the behavioral profile of BDNF heterozygous knockout and wild-type 
      mice. The heterozygous and wild-type mice did not differ on measures of activity, 
      exploration, or hedonic sensitivity, or in the forced swim test. When assessed in 
      the learned helplessness paradigm, heterozygous mice were slower to escape after 
      training than were wild-type mice (p = .02). This effect may be accounted for by 
      the fact that these mice demonstrate a reduced sensitivity to centrally mediated 
      pain, apparent on the hot plate and Formalin injection tests of nociception. 
      Overall, heterozygous mice were not more likely to display anxious or 
      depressive-like behaviors and, consequently, may not constitute a murine model of 
      genetic vulnerability to mood and anxiety disorders.
FAU - MacQueen, G M
AU  - MacQueen GM
AD  - Department of Psychiatry and Behavioral Neurosciences, McMaster University 
      Medical Centre, Hamilton, Ontario, Canada. macqueng@mcmaster.ca
FAU - Ramakrishnan, K
AU  - Ramakrishnan K
FAU - Croll, S D
AU  - Croll SD
FAU - Siuciak, J A
AU  - Siuciak JA
FAU - Yu, G
AU  - Yu G
FAU - Young, L T
AU  - Young LT
FAU - Fahnestock, M
AU  - Fahnestock M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Behav Neurosci
JT  - Behavioral neuroscience
JID - 8302411
RN  - 0 (Brain-Derived Neurotrophic Factor)
SB  - IM
MH  - Affect/*physiology
MH  - Animals
MH  - Arousal/*genetics/physiology
MH  - Avoidance Learning/physiology
MH  - Brain-Derived Neurotrophic Factor/genetics/physiology
MH  - Escape Reaction/physiology
MH  - Exploratory Behavior/physiology
MH  - Female
MH  - Helplessness, Learned
MH  - Heterozygote
MH  - Male
MH  - Mice
MH  - Mice, Knockout
MH  - *Motivation
MH  - Pain Threshold/*physiology
EDAT- 2001/10/05 10:00
MHDA- 2002/02/05 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/02/05 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - 10.1037//0735-7044.115.5.1145 [doi]
PST - ppublish
SO  - Behav Neurosci. 2001 Oct;115(5):1145-53. doi: 10.1037//0735-7044.115.5.1145.