PMID- 11585623
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 119
IP  - 2
DP  - 2001 Oct 1
TI  - Cuprizone and piperonyl butoxide, proposed inhibitors of T-cell function, 
      attenuate experimental allergic encephalomyelitis in SJL mice.
PG  - 205-13
AB  - Multiple sclerosis (MS) and its animal model, experimental allergic 
      encephalomyelitis (EAE), are autoimmune demyelinating diseases with autoreactive 
      T-cells acting as important mediators of pathogenesis. Cuprizone, a copper 
      chelator, and piperonyl butoxide (PBO), a pesticide synergist, are implicated to 
      inhibit T-cell activation and function. The purpose of this study was to assess 
      whether either of these agents would suppress PLP-peptide-induced EAE in the SJL 
      mouse. Indeed, treatment with cuprizone beginning 1 week prior to disease 
      induction, and PBO administration from days 1 to 9 of EAE, significantly 
      attenuated EAE clinical severity. Furthermore, both agents decreased blood 
      CD4+/CD8+ ratios, and reduced signs of chronic graft vs. host disease (GVHD) 
      indicating attenuation of an immune T-cell response. These results suggest that 
      cuprizone and PBO suppress EAE and use of these agents will provide insights into 
      the mechanisms of T-cell mediated diseases.
FAU - Emerson, M R
AU  - Emerson MR
AD  - Department of Molecular and Integrative Physiology, University of Kansas Medical 
      Center, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA.
FAU - Biswas, S
AU  - Biswas S
FAU - LeVine, S M
AU  - LeVine SM
LA  - eng
GR  - HD 02528/HD/NICHD NIH HHS/United States
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Research Support, U.S. Gov't, P.H.S.
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Chelating Agents)
RN  - 0 (Pesticide Synergists)
RN  - 5N16U7E0AO (Cuprizone)
RN  - LWK91TU9AH (Piperonyl Butoxide)
SB  - IM
MH  - Animals
MH  - CD4-CD8 Ratio
MH  - Chelating Agents/*pharmacology
MH  - Chronic Disease
MH  - Cuprizone/*pharmacology
MH  - Encephalomyelitis, Autoimmune, Experimental/drug therapy/*immunology
MH  - Female
MH  - Graft vs Host Disease/drug therapy/immunology/mortality
MH  - Male
MH  - Mice
MH  - Mice, Inbred BALB C
MH  - Mice, Inbred C57BL
MH  - Multiple Sclerosis/drug therapy/immunology
MH  - Pesticide Synergists/*pharmacology
MH  - Piperonyl Butoxide/*pharmacology
MH  - Survival Rate
MH  - T-Lymphocytes/drug effects/*immunology
EDAT- 2001/10/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - S0165572801003940 [pii]
AID - 10.1016/s0165-5728(01)00394-0 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2001 Oct 1;119(2):205-13. doi: 10.1016/s0165-5728(01)00394-0.