PMID- 11585631
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190826
IS  - 0165-5728 (Print)
IS  - 0165-5728 (Linking)
VI  - 119
IP  - 2
DP  - 2001 Oct 1
TI  - Assessment of HIV-intrathecal humoral immune response in AIDS-related 
      neurological disorders.
PG  - 278-86
AB  - Intrathecal synthesis of IgG directed to HIV antigens was investigated by 
      antibody specific index (ASI), affinity-mediated immunoblot (AMI) and Western 
      blot (WB) assay in a group of 88 AIDS patients of which 28 with HIV-associated 
      neurological disorders (HAND), 13 without associated neurological disorders 
      (WAND) and 47 with non-HIV-associated neurological disorders (non-HAND). CD4+ 
      count was above 50 cells/mm3 (CD4+>50) in 30 and below 50/mm3 (CD4+<50) in 58 
      patients, respectively. A significantly higher frequency for CSF complete 
      anti-gag profile (p<0.001), and for HIV-specific oligoclonal patterns ("mixed" 
      pattern=p<0.01) was observed in HAND as compared to patterns from the other 
      clinical groups. A decrease in complete anti-env, anti-pol and anti-gag 
      reactivity was present in CSF of patients with CD4+<50 as compared to those with 
      CD4+>50. Our findings suggest that AIDS appears to be characterized by an 
      anti-HIV intrathecal humoral immune response which is principally directed to env 
      products with a prevalence of oligoclonal patterns and CSF complete anti-gag 
      profile in HIV-associated neurological involvement.
FAU - Fainardi, E
AU  - Fainardi E
AD  - Section of Neurology, University of Ferrara, Arcispedale S. Anna, Corso della 
      Giovecca 203, 1-44100, Ferrara, Italy. henryfai@tin.it
FAU - Contini, C
AU  - Contini C
FAU - Benassi, N
AU  - Benassi N
FAU - Bedetti, A
AU  - Bedetti A
FAU - Castellazzi, M
AU  - Castellazzi M
FAU - Vaghi, L
AU  - Vaghi L
FAU - Govoni, V
AU  - Govoni V
FAU - Paolino, E
AU  - Paolino E
FAU - Balboni, P
AU  - Balboni P
FAU - Granieri, E
AU  - Granieri E
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Neuroimmunol
JT  - Journal of neuroimmunology
JID - 8109498
RN  - 0 (Gene Products, env)
RN  - 0 (Gene Products, gag)
RN  - 0 (HIV Antibodies)
RN  - 0 (Immunoglobulin G)
SB  - IM
MH  - AIDS Dementia Complex/*immunology
MH  - Adult
MH  - Antibody Formation/*immunology
MH  - Antibody Specificity
MH  - Blotting, Western
MH  - CD4 Lymphocyte Count
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Products, env/immunology
MH  - Gene Products, gag/immunology
MH  - HIV Antibodies/analysis/blood/*cerebrospinal fluid
MH  - Humans
MH  - Immunoglobulin G/analysis/blood/cerebrospinal fluid
MH  - Male
MH  - Prospective Studies
EDAT- 2001/10/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - S0165572801003861 [pii]
AID - 10.1016/s0165-5728(01)00386-1 [doi]
PST - ppublish
SO  - J Neuroimmunol. 2001 Oct 1;119(2):278-86. doi: 10.1016/s0165-5728(01)00386-1.