PMID- 11586280
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190723
IS  - 0091-6749 (Print)
IS  - 0091-6749 (Linking)
VI  - 108
IP  - 4 Suppl
DP  - 2001 Oct
TI  - Use of intravenous gamma globulins in neuroimmunologic diseases.
PG  - S126-32
AB  - Intravenous gamma globulin (IVIg) is used in the treatment of immunologic 
      diseases that affect the entire neuroaxis, including the brain, spinal cord, 
      peripheral nerves, muscles, and neuromuscular junction. The panel reviewed the 
      available literature on the use of IVIg in order to evaluate the efficacy of this 
      therapy in neuroimmunologic diseases. In prospective, rigorously controlled, 
      double-blinded clinical trials, IVIg was found to have proven efficacy in the 
      Guillain-Barre syndrome, chronic inflammatory demyelinating polyneuropathy, 
      multifocal motor neuropathy, dermatomyositis, and Lambert-Eaton myasthenic 
      syndrome. It was found to be probably effective in myasthenia gravis and 
      polymyositis, and possibly effective in several other neuroimmunologic diseases. 
      Further studies are needed to evaluate the use of IVIg for neuroimmunologic 
      diseases in which its efficacy is suspected but not proven and to elucidate its 
      mechanisms of action.
FAU - Latov, N
AU  - Latov N
AD  - Columbia University, New York, NY, USA.
FAU - Chaudhry, V
AU  - Chaudhry V
FAU - Koski, C L
AU  - Koski CL
FAU - Lisak, R P
AU  - Lisak RP
FAU - Apatoff, B R
AU  - Apatoff BR
FAU - Hahn, A F
AU  - Hahn AF
FAU - Howard, J F Jr
AU  - Howard JF Jr
LA  - eng
PT  - Journal Article
PT  - Review
PL  - United States
TA  - J Allergy Clin Immunol
JT  - The Journal of allergy and clinical immunology
JID - 1275002
RN  - 0 (Immunoglobulins, Intravenous)
SB  - IM
MH  - Clinical Trials as Topic
MH  - Humans
MH  - Immune System Diseases/*therapy
MH  - Immunoglobulins, Intravenous/*therapeutic use
MH  - Nervous System Diseases/*therapy
RF  - 74
EDAT- 2001/10/05 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/05 10:00
PHST- 2001/10/05 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/05 10:00 [entrez]
AID - a118300 [pii]
AID - 10.1067/mai.2001.118300 [doi]
PST - ppublish
SO  - J Allergy Clin Immunol. 2001 Oct;108(4 Suppl):S126-32. doi: 
      10.1067/mai.2001.118300.