PMID- 11586282 OWN - NLM STAT- MEDLINE DCOM- 20011204 LR - 20190723 IS - 0091-6749 (Print) IS - 0091-6749 (Linking) VI - 108 IP - 4 Suppl DP - 2001 Oct TI - Intravenous immunoglobulin consensus statement. PG - S139-46 AB - Intravenous immunoglobulin (IVIG) preparations are a mainstay for a number of disorders that include primary immuno-deficiency, acute inflammatory conditions, hematological disorders, infections, and neuroimmunological disorders. The range of therapeutic activity is attributed to IVIG's myriad action mechanisms. IVIG can interact and bind onto complement factors, which can prevent complement-mediated tissue damage, modulate T-lymphocytes, alter cytokine profiles, and modulate the immune system. These interactions can act alone or in combination to maintain immune balance while preserving homeostasis. A consensus panel was convened in 2000 to evaluate and define new advances in IVIG therapies. FAU - Sacher, R A AU - Sacher RA AD - University of Cincinnati Medical Center, OH 45267-0055, USA. CN - IVIG Advisory Panel LA - eng PT - Consensus Development Conference PT - Journal Article PT - Review PL - United States TA - J Allergy Clin Immunol JT - The Journal of allergy and clinical immunology JID - 1275002 RN - 0 (Immunoglobulins, Intravenous) SB - IM MH - Female MH - Humans MH - Immunoglobulins, Intravenous/*therapeutic use MH - Pregnancy RF - 76 EDAT- 2001/10/05 10:00 MHDA- 2002/01/05 10:01 CRDT- 2001/10/05 10:00 PHST- 2001/10/05 10:00 [pubmed] PHST- 2002/01/05 10:01 [medline] PHST- 2001/10/05 10:00 [entrez] AID - a118640 [pii] AID - 10.1067/mai.2001.118640 [doi] PST - ppublish SO - J Allergy Clin Immunol. 2001 Oct;108(4 Suppl):S139-46. doi: 10.1067/mai.2001.118640.