PMID- 11588593
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20190718
IS  - 0959-4965 (Print)
IS  - 0959-4965 (Linking)
VI  - 12
IP  - 13
DP  - 2001 Sep 17
TI  - BDNF and NT3 extend the critical period for developmental climbing fibre 
      plasticity.
PG  - 2871-4
AB  - The effect on neonatal brain plasticity of two neurotrophins, brain derived 
      neurotrophic factor (BDNF) and neurotrophin-3 (NT-3), was studied using the rat 
      olivocerebellar projection as a model. Unilateral transection of climbing fibres 
      (CFs) in the rat before postnatal day 7 induces reinnervation of the deafferented 
      hemicerebellum, but this does not occur if the transection is performed after 
      postnatal day 10. Eleven-day-old day rats underwent unilateral CF transection 
      followed by neurotrophin injection into the denervated cerebellar cortex 24 h 
      later. The exogenous neurotrophins induced CF reinnervation of the denervated 
      hemicerebellum. However BDNF was more efficacious than NT-3. Thus two 
      neurotrophins can extend the window of neonatal brain plasticity, therefore 
      suggesting potential therapeutic use after brain trauma.
FAU - Sherrard, R M
AU  - Sherrard RM
AD  - School of Medicine, James Cook University, Townsville, Queensland 4811, 
      Australia.
FAU - Bower, A J
AU  - Bower AJ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - Neuroreport
JT  - Neuroreport
JID - 9100935
RN  - 0 (Amidines)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Cytochrome c Group)
RN  - 0 (Fluorescent Dyes)
RN  - 0 (Neurotrophin 3)
RN  - 0 (diamidino compound 253-50)
SB  - IM
MH  - Afferent Pathways/cytology/drug effects/*growth & development
MH  - Aging/physiology
MH  - Amidines/pharmacokinetics
MH  - Animals
MH  - Animals, Newborn
MH  - Axons/*drug effects/ultrastructure
MH  - Brain-Derived Neurotrophic Factor/metabolism/*pharmacology
MH  - Cell Count
MH  - Cerebellum/cytology/drug effects/*growth & development
MH  - Cytochrome c Group/pharmacokinetics
MH  - Denervation
MH  - Dose-Response Relationship, Drug
MH  - Fluorescent Dyes/pharmacokinetics
MH  - Nerve Regeneration/drug effects/physiology
MH  - Neuronal Plasticity/*drug effects/physiology
MH  - Neurotrophin 3/*pharmacology
MH  - Olivary Nucleus/cytology/drug effects/*growth & development
MH  - Rats
MH  - Rats, Wistar
EDAT- 2001/10/06 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/06 10:00
PHST- 2001/10/06 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/06 10:00 [entrez]
AID - 10.1097/00001756-200109170-00023 [doi]
PST - ppublish
SO  - Neuroreport. 2001 Sep 17;12(13):2871-4. doi: 10.1097/00001756-200109170-00023.