PMID- 11589772
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20190921
IS  - 0106-9543 (Print)
IS  - 0106-9543 (Linking)
VI  - 21
IP  - 5
DP  - 2001 Oct
TI  - The insulin-like growth factor binding protein 3 ternary complex is reduced in 
      cirrhosis.
PG  - 350-6
AB  - BACKGROUND/AIMS: In healthy adults, serum insulin-like growth factor I (IGF-I), 
      IGF binding protein 3 (IGFBP-3) and acid labile subunit (ALS) form a 150-kDa 
      ternary complex under the control of growth hormone (GH). Approximately 80-90% of 
      circulating IGF-I is bound to the ternary complex. In cirrhosis the GH/IGF axis 
      is severely disturbed and the individual components of the ternary complex are 
      reduced. However, the degree of ternary complex formation in cirrhosis has not 
      previously been described. METHODS: Serum IGF-I, IGFBP-3, ALS, the 150-kDa 
      ternary complex and IGFBP-3 proteolysis were all measured in six compensated and 
      six decompensated cirrhotic patients and compared to six healthy controls. 
      RESULTS: Patients with compensated cirrhosis had decreased levels of IGF-I (55%), 
      IGFBP-3 (64%) and ALS (53%), and in the decompensated patients these levels were 
      decreased even further: IGF-I (32%), IGFBP-3 (37%) and ALS (27%) compared to 
      healthy controls. The levels of the ternary complex followed this pattern, with 
      low levels seen in the compensated patients (66%) and a further reduction in the 
      decompensated patients (27%). Ternary complex levels correlated negatively with 
      the Child-Pugh score. No increase in IGFBP-3 proteolysis was found in cirrhotic 
      patients compared to healthy controls. CONCLUSION: Cirrhosis is associated with 
      reduced levels of the 150-kDa ternary IGFBP-3 complex correlating with the degree 
      of liver disease.
FAU - Ottesen, L H
AU  - Ottesen LH
AD  - Department of Hepatology V, University of Copenhagen, Copenhagen, Denmark. 
      lo@farm.au.dk
FAU - Bendtsen, F
AU  - Bendtsen F
FAU - Flyvbjerg, A
AU  - Flyvbjerg A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Denmark
TA  - Liver
JT  - Liver
JID - 8200939
RN  - 0 (Carrier Proteins)
RN  - 0 (Glycoproteins)
RN  - 0 (Insulin-Like Growth Factor Binding Protein 3)
RN  - 0 (insulin-like growth factor binding protein, acid labile subunit)
RN  - 67763-96-6 (Insulin-Like Growth Factor I)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Carrier Proteins/blood
MH  - Glycoproteins/blood
MH  - Humans
MH  - Insulin-Like Growth Factor Binding Protein 3/*blood
MH  - Insulin-Like Growth Factor I/analysis
MH  - Liver Cirrhosis/*blood/physiopathology
MH  - Middle Aged
EDAT- 2001/10/09 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/10/09 10:00
PHST- 2001/10/09 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/10/09 10:00 [entrez]
AID - 210508 [pii]
AID - 10.1034/j.1600-0676.2001.210508.x [doi]
PST - ppublish
SO  - Liver. 2001 Oct;21(5):350-6. doi: 10.1034/j.1600-0676.2001.210508.x.