PMID- 11591879
OWN - NLM
STAT- MEDLINE
DCOM- 20011204
LR  - 20191105
IS  - 1526-484X (Print)
IS  - 1526-484X (Linking)
VI  - 11
IP  - 3
DP  - 2001 Sep
TI  - Short-term high-fat diet alters substrate utilization during exercise but not 
      glucose tolerance in highly trained athletes.
PG  - 273-86
AB  - We determined the effect of a high-fat diet and carbohydrate (CHO) restoration on 
      substrate oxidation and glucose tolerance in 7 competitive ultra-endurance 
      athletes (peak oxygen uptake [VO(2peak)] 68 +/- 1 ml x kg(-1) x min(-1); mean +/- 
      SEM). For 6 days, subjects consumed a random order of a high-fat (69% fat; 
      FAT-adapt) or a high-CHO (70% CHO; HCHO) diet, each followed by 1 day of a 
      high-CHO diet. Treatments were separated by an 18-day wash out. Substrate 
      oxidation was determined during submaximal cycling (20 min at 65% VO(2peak)) 
      prior to and following the 6 day dietary interventions. Fat oxidation at baseline 
      was not different between treatments (17.4 +/- 2.1 vs. 16.1 +/- 1.3 g x 20 
      min(-1) for FAT-adapt and HCHO, respectively) but increased 34% after 6 days of 
      FAT-adapt (to 23.3 +/- 0.9 g x 20 min(-1), p < .05) and decreased 30% after HCHO 
      (to 11.3 +/- 1.4 g x 20 min(-1), p < .05). Glucose tolerance, determined by the 
      area under the plasma [glucose] versus time curve during an oral glucose 
      tolerance (OGTT) test, was similar at baseline (545 +/- 21 vs. 520 +/- 28 mmol x 
      L(-1) x 90 min(-1)), after 5-d of dietary intervention (563 +/- 26 vs. 520 +/-18 
      mmol x L(-1) x 90 min(-1)) and after 1 d of high-CHO (491 +/- 28 vs. 489 +/- 22 
      mmol x L(-1) x 90 min(-1) for FAT- adapt and HCHO, respectively). An index of 
      whole-body insulin sensitivity ( S(I), 10000/divided by fasting [glucose] x 
      fasting [insulin] x mean [glucose] during OGTT x mean [insulin] during OGTT) was 
      similar at baseline (15 +/- 2 vs. 17 +/- 5 arbitrary units), after 5-d of dietary 
      intervention (15 +/- 2 vs. 15 +/- 2) and after 24 h of CHO loading (17 +/- 3 vs. 
      18 +/- 2 for FAT- adapt and HCHO, respectively). We conclude that despite marked 
      changes in the pattern of substrate oxidation during submaximal exercise, 
      short-term adaptation to a high-fat diet does not alter whole-body glucose 
      tolerance or an index of insulin sensitivity in highly-trained individuals.
FAU - Staudacher, H M
AU  - Staudacher HM
AD  - Exercise Metabolism Group, School of Medical Sciences, RMIT University, Bundoora, 
      Victoria 3083, Australia.
FAU - Carey, A L
AU  - Carey AL
FAU - Cummings, N K
AU  - Cummings NK
FAU - Hawley, J A
AU  - Hawley JA
FAU - Burke, L M
AU  - Burke LM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Int J Sport Nutr Exerc Metab
JT  - International journal of sport nutrition and exercise metabolism
JID - 100939812
RN  - 0 (Blood Glucose)
RN  - 0 (Dietary Fats)
RN  - 0 (Insulin)
SB  - IM
MH  - Adult
MH  - Blood Glucose/*metabolism
MH  - Dietary Fats/administration & dosage/*metabolism
MH  - *Exercise
MH  - Glucose Tolerance Test
MH  - Humans
MH  - Insulin/blood
MH  - Male
MH  - Time Factors
EDAT- 2001/10/10 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/10 10:00
PHST- 2001/10/10 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/10 10:00 [entrez]
AID - 10.1123/ijsnem.11.3.273 [doi]
PST - ppublish
SO  - Int J Sport Nutr Exerc Metab. 2001 Sep;11(3):273-86. doi: 
      10.1123/ijsnem.11.3.273.