PMID- 11592854
OWN - NLM
STAT- MEDLINE
DCOM- 20020123
LR  - 20131121
IS  - 0969-9961 (Print)
IS  - 0969-9961 (Linking)
VI  - 8
IP  - 5
DP  - 2001 Oct
TI  - Potential role of endogenous brain-derived neurotrophic factor in long-term 
      neuronal reorganization of the superior colliculus after bilateral visual 
      deprivation.
PG  - 866-80
AB  - The role of the brain-derived neurotrophic factor (BDNF), the BDNF receptor 
      (TrkB), and the glutamic acid decarboxylase (GAD67) after neonatal, bilateral 
      nerve deafferentiation during postnatal development was investigated in the rat 
      superior colliculus (SC). BDNF and GAD67 mRNA expression were significantly 
      increased in optic (Op) and intermediate gray (InG) layers at 5, 8, 15, and 21 
      days after birth, but not in adult animals. However, TrkB mRNA expression was not 
      modified at any time tested. At 15 days, where changes in BDNF and GAD67 mRNAs 
      were more evident, an upregulation of the NMDAR(1A) mRNA glutamate receptor in 
      the Op and InG, a modification in the pattern of synaptic zinc in the superficial 
      layers of SC, and an increased synaptophysin immunoreactivity in the Op was 
      found. This indicates the existence of a synergic mechanism between BDNF and NMDA 
      to determine refinement of connections after the loss of visual input in SC.
CI  - Copyright 2001 Academic Press.
FAU - Vizuete, M L
AU  - Vizuete ML
AD  - Departamento de Bioquimica, Bromatologia y Toxicologia, Facultad de Farmacia, 
      Universidad de Sevilla, Sevilla, 41012, Spain.
FAU - Venero, J L
AU  - Venero JL
FAU - Vargas, C
AU  - Vargas C
FAU - Revuelta, M
AU  - Revuelta M
FAU - Machado, A
AU  - Machado A
FAU - Cano, J
AU  - Cano J
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Neurobiol Dis
JT  - Neurobiology of disease
JID - 9500169
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (Isoenzymes)
RN  - 0 (NMDA receptor A1)
RN  - 0 (Nerve Tissue Proteins)
RN  - 0 (RNA, Messenger)
RN  - 0 (Receptors, N-Methyl-D-Aspartate)
RN  - 0 (Synaptophysin)
RN  - 6384-92-5 (N-Methylaspartate)
RN  - EC 2.7.10.1 (Receptor, trkB)
RN  - EC 4.1.1.15 (Glutamate Decarboxylase)
RN  - EC 4.1.1.15 (glutamate decarboxylase 1)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Animals
MH  - Animals, Newborn
MH  - Blindness/*physiopathology
MH  - Brain-Derived Neurotrophic Factor/biosynthesis/genetics/*physiology
MH  - Eye Enucleation
MH  - Glutamate Decarboxylase/biosynthesis/genetics
MH  - In Situ Hybridization
MH  - Isoenzymes/biosynthesis/genetics
MH  - Male
MH  - N-Methylaspartate/physiology
MH  - Nerve Tissue Proteins/analysis/biosynthesis/genetics/*physiology
MH  - Neuronal Plasticity/*genetics/physiology
MH  - RNA, Messenger/biosynthesis/genetics
MH  - Rats
MH  - Rats, Wistar
MH  - Receptor, trkB/biosynthesis/genetics/*physiology
MH  - Receptors, N-Methyl-D-Aspartate/biosynthesis/genetics/*physiology
MH  - Signal Transduction
MH  - Superior Colliculi/*metabolism
MH  - Synapses/metabolism/ultrastructure
MH  - Synaptophysin/analysis
MH  - Zinc/analysis
EDAT- 2001/10/11 10:00
MHDA- 2002/01/24 10:01
CRDT- 2001/10/11 10:00
PHST- 2001/10/11 10:00 [pubmed]
PHST- 2002/01/24 10:01 [medline]
PHST- 2001/10/11 10:00 [entrez]
AID - S0969-9961(01)90424-3 [pii]
AID - 10.1006/nbdi.2001.0424 [doi]
PST - ppublish
SO  - Neurobiol Dis. 2001 Oct;8(5):866-80. doi: 10.1006/nbdi.2001.0424.