PMID- 11593175
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20131121
IS  - 0194-5998 (Print)
IS  - 0194-5998 (Linking)
VI  - 125
IP  - 4
DP  - 2001 Oct
TI  - Proton pump inhibitor resistance in the treatment of laryngopharyngeal reflux.
PG  - 374-8
AB  - OBJECTIVE: To describe the occurrence of relative proton pump inhibitor (PPI) 
      drug resistance in the treatment of laryngopharyngeal reflux (LPR). STUDY DESIGN 
      AND SETTING: A retrospective review was performed for 1053 consecutive adults 
      undergoing double-probe (simultaneous esophageal and pharyngeal) pH testing in 
      our laboratory. Two hundred five patients who had pH studies performed while 
      taking at least a daily dose of PPI therapy were identified; 167 qualified for 
      further analysis. The pH data was reviewed for the presence of abnormalities in 
      either esophageal or pharyngeal acid exposure to evaluate drug efficacy. RESULTS: 
      Forty-four percent (74/167) of the study patients demonstrated abnormal levels of 
      acid exposure. Results were further analyzed to compare failure rates based on 
      different dosage regimens. Patients on once daily doses of PPI failed at a rate 
      of 56%, with lower failure rates for higher-dose regimens. CONCLUSIONS: A 
      significant number of LPR patients on PPI therapy demonstrate relative drug 
      resistance.
FAU - Amin, M R
AU  - Amin MR
AD  - Department of Otolaryngology, MCP/Hahnemann School of Medicine, Two Logan Square, 
      Philadelphia, PA 19103, USA. mamin@drexel.edu
FAU - Postma, G N
AU  - Postma GN
FAU - Johnson, P
AU  - Johnson P
FAU - Digges, N
AU  - Digges N
FAU - Koufman, J A
AU  - Koufman JA
LA  - eng
PT  - Journal Article
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
RN  - 0 (2-Pyridinylmethylsulfinylbenzimidazoles)
RN  - 0 (Proton Pump Inhibitors)
RN  - 0K5C5T2QPG (Lansoprazole)
RN  - KG60484QX9 (Omeprazole)
SB  - IM
MH  - 2-Pyridinylmethylsulfinylbenzimidazoles
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Female
MH  - Humans
MH  - Lansoprazole
MH  - Laryngeal Diseases/complications/*drug therapy
MH  - Male
MH  - Middle Aged
MH  - Omeprazole/*analogs & derivatives/*therapeutic use
MH  - Pharyngeal Diseases/complications/*drug therapy
MH  - *Proton Pump Inhibitors
MH  - Retrospective Studies
MH  - Treatment Failure
EDAT- 2001/10/11 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/11 10:00
PHST- 2001/10/11 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/11 10:00 [entrez]
AID - S0194-5998(01)02959-X [pii]
AID - 10.1067/mhn.2001.118691 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2001 Oct;125(4):374-8. doi: 10.1067/mhn.2001.118691.