PMID- 11593591
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20220408
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 112
IP  - 2
DP  - 1999 Feb
TI  - Clinical hereditary characteristics in nasopharyngeal carcinoma through 
      Ye-Liang's family cluster.
PG  - 185-7
AB  - OBJECTIVE: To investigate the incidence of nasopharyngeal carcinoma (NPC) and the 
      clinical characteristics in this family through a long-term follow-up, and to 
      seek the hereditary factor of NPC. This research was also designed to provide 
      some clinical data for etiological study. METHODS: A genealogical tree of 
      Ye-Liang's family was drawn and reported in 1972 after a complete survey. Further 
      follow-up from that time to 1997 was performed. Human leucocyte antigens (HLA) 
      were investigated, and physical follow-up was done in domestic members of this 
      family. For oversea members of this family, correspondence follow-up was 
      performed. RESULTS: In the last 25 years, the incidence of malignancies in 
      Ye-Liang's family increased from 10 cases to 18 cases, and incidence of NPC 
      increased from 9 cases to 15 cases. In this family, not only multiple 
      malignancies have been found in the second generation, but also NPC has been 
      found in the third generation. HLA-[A2-B46] haplotype was correlated with 
      occurrence of NPC. CONCLUSIONS: Dominant racial predilection and family cluster 
      in NPC implied that NPC is a heredity-related cancer which might involve 
      multifactorial disorders in carcinogenesis. Further research on etiology of NPC 
      should be focused on hereditary factor. Detection of inherited factors should be 
      performed for forecast of carcinogenesis and reduction of NPC occurrence.
FAU - Zhang, F
AU  - Zhang F
AD  - Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yat-Sen University of 
      Medical Sciences, Guangzhou 510060, China.
FAU - Zhang, J
AU  - Zhang J
LA  - eng
PT  - Journal Article
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (HLA-A2 Antigen)
RN  - 0 (HLA-B Antigens)
RN  - 0 (HLA-B46 antigen)
SB  - IM
MH  - Female
MH  - Follow-Up Studies
MH  - Genetic Predisposition to Disease
MH  - HLA-A2 Antigen/*blood
MH  - HLA-B Antigens/*blood
MH  - Humans
MH  - Male
MH  - Multigene Family
MH  - Nasopharyngeal Neoplasms/*genetics
MH  - Pedigree
EDAT- 2001/10/12 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
PST - ppublish
SO  - Chin Med J (Engl). 1999 Feb;112(2):185-7.