PMID- 11593901
OWN - NLM
STAT- MEDLINE
DCOM- 20011025
LR  - 20161124
IS  - 0036-7281 (Print)
IS  - 0036-7281 (Linking)
VI  - 143
IP  - 9
DP  - 2001 Sep
TI  - [Oxygen deficiency and erythropoietin].
PG  - 455-60
AB  - Reduced oxygenation activates specific expression of erythropoietin (EPO) and 
      other hypoxia-regulated genes. The cellular response to hypoxia is mediated by 
      the hypoxia-inducible factor-1 (HIF-1). Unregulated overexpression of EPO results 
      in a hematocrit value of about 80%; transgenic mice were shown to adapt to this 
      polyglobulia.
FAU - Gassmann, M
AU  - Gassmann M
AD  - Physiologisches Institut der Universitat Zurich. maxg@access.unizh.ch
LA  - ger
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
TT  - Sauerstoffmangel und Erythropoietin.
PL  - Switzerland
TA  - Schweiz Arch Tierheilkd
JT  - Schweizer Archiv fur Tierheilkunde
JID - 0424247
RN  - 0 (DNA-Binding Proteins)
RN  - 0 (Hif1a protein, mouse)
RN  - 0 (Hypoxia-Inducible Factor 1)
RN  - 0 (Hypoxia-Inducible Factor 1, alpha Subunit)
RN  - 0 (Nuclear Proteins)
RN  - 0 (Transcription Factors)
RN  - 11096-26-7 (Erythropoietin)
RN  - S88TT14065 (Oxygen)
SB  - IM
MH  - Animals
MH  - DNA-Binding Proteins/genetics/*metabolism
MH  - Erythropoietin/genetics/*metabolism
MH  - Gene Expression
MH  - Gene Expression Regulation/*physiology
MH  - Hematocrit/veterinary
MH  - Hypoxia/physiopathology/*veterinary
MH  - Hypoxia-Inducible Factor 1
MH  - Hypoxia-Inducible Factor 1, alpha Subunit
MH  - Mice
MH  - Mice, Transgenic
MH  - Nuclear Proteins/genetics/*metabolism
MH  - Oxygen/metabolism
MH  - *Transcription Factors
RF  - 30
EDAT- 2001/10/12 10:00
MHDA- 2001/10/26 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2001/10/26 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
PST - ppublish
SO  - Schweiz Arch Tierheilkd. 2001 Sep;143(9):455-60.