PMID- 11594518
OWN - NLM
STAT- MEDLINE
DCOM- 20020912
LR  - 20191025
IS  - 0925-5710 (Print)
IS  - 0925-5710 (Linking)
VI  - 74
IP  - 2
DP  - 2001 Aug
TI  - Remission of acute myeloblastic leukemia after severe pneumonia treated with 
      high-dose methylprednisolone.
PG  - 173-7
AB  - We report a case of acute myeloblastic leukemia (AML)-M2 (by 
      French-American-British classification) with t(8;21) (q22:q22) that was 
      complicated with severe pneumonia. The patient tested positive by fluorescence in 
      situ hybridization (FISH) for AML1 splitting and positive by reverse 
      transcriptase polymerase chain reaction (RT-PCR) for chimeric AML1/MTG8 messenger 
      RNA (mRNA), which indicated splitting of the MTG8 gene on chromosome 8 (q22) and 
      the AMLI gene on chromosome 22 (q22). High-dose methylprednisolone was 
      administered, and the leukemic cells disappeared without chemotherapy, although 
      dysplastic hematopoietic cells were observed transiently after the first therapy. 
      After the disappearance of leukemic cells, FISH for AML1 splitting was negative, 
      and real-time PCR results for quantitative chimeric AML1/ MTG8 mRNA were less 
      than the detectable level, however, RT-PCR results for AML1/MTG8 mRNA remained 
      positive. These findings suggest that the patient acquired morphological, 
      cytogenetic. and possibly molecular genetic remission by the synergistic effects 
      of severe infection and high-dose methylprednisolone.
FAU - Shimohakamada, Y
AU  - Shimohakamada Y
AD  - Department of Medicine, Yamaguchi Prefecture Central Hospital, Hofu, Japan.
FAU - Shinohara, K
AU  - Shinohara K
FAU - Fukuda, N
AU  - Fukuda N
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - Japan
TA  - Int J Hematol
JT  - International journal of hematology
JID - 9111627
RN  - 0 (Anti-Inflammatory Agents)
RN  - X4W7ZR7023 (Methylprednisolone)
SB  - IM
MH  - Aged
MH  - Anti-Inflammatory Agents/*administration & dosage
MH  - Cytogenetic Analysis
MH  - Female
MH  - Humans
MH  - Leukemia, Myeloid, Acute/*complications/diagnosis/genetics
MH  - Methylprednisolone/*administration & dosage
MH  - Pneumonia/*drug therapy/etiology
MH  - Remission, Spontaneous
EDAT- 2001/10/12 10:00
MHDA- 2002/09/13 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/09/13 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - 10.1007/BF02982001 [doi]
PST - ppublish
SO  - Int J Hematol. 2001 Aug;74(2):173-7. doi: 10.1007/BF02982001.