PMID- 11594585
OWN - NLM
STAT- MEDLINE
DCOM- 20011101
LR  - 20190616
IS  - 0077-8923 (Print)
IS  - 0077-8923 (Linking)
VI  - 941
DP  - 2001 Sep
TI  - The role of human T cell lymphotropic virus type I tax in the development of 
      cutaneous T cell lymphoma.
PG  - 86-96
AB  - Although it has been well established that the human T cell lymphotropic virus 
      type I (HTLV-I) causes adult T cell leukemia/lymphoma (ATLL) in regions of the 
      world where this virus is endemic, its role in the pathogenesis of cutaneous T 
      cell lymphoma (CTCL) in the Western world has been less well established. Most 
      patients with CTCL are negative for antibodies to the structural proteins of 
      HTLV-I, and thus a causative role for this virus is usually dismissed. However, 
      the Tax sequence of HTLV-I has been found in the peripheral blood mononuclear 
      cells of practically all patients with CTCL. Such patients express Tax mRNA and 
      have antibodies to p40Tax, the protein encoded by this sequence. Sequence 
      analysis of a 159-bp region of Tax extracted from CTCL cells proved to be 
      homologous with the same region prepared from a cell line infected with 
      prototypic HTLV-I. By in situ PCR, Tax has been demonstrated in the lymphocytes 
      infiltrating the skin as well as in the keratinocytes of such patients. Apart 
      from the pathophysiologic and clinical interest of these studies, these 
      observations may have therapeutic implications. In vitro, the proliferation of 
      HTLV-I-transformed cells can be inhibited by antisense to HTLV-I Tax. Since Tax 
      has not been identified in the normal human genome, antisense to Tax deserves 
      serious consideration as a treatment modality for patients whose cells have been 
      demonstrated to harborTax.
FAU - Zucker-Franklin, D
AU  - Zucker-Franklin D
AD  - Department of Medicine, New York University School of Medicine, New York 10016, 
      USA. Dorothea.Zucker-Franklin@med.nyu.edu
LA  - eng
PT  - Journal Article
PL  - United States
TA  - Ann N Y Acad Sci
JT  - Annals of the New York Academy of Sciences
JID - 7506858
RN  - 0 (DNA, Viral)
RN  - 0 (Gene Products, tax)
RN  - 0 (Oligonucleotides, Antisense)
RN  - 0 (RNA, Viral)
SB  - IM
MH  - Cell Division
MH  - Cell Line
MH  - DNA, Viral/analysis
MH  - Gene Products, tax/genetics/*physiology
MH  - HTLV-I Infections/pathology
MH  - Human T-lymphotropic virus 1/genetics/*isolation & purification
MH  - Humans
MH  - In Situ Hybridization
MH  - Leukemia-Lymphoma, Adult T-Cell/pathology
MH  - Leukocytes, Mononuclear/virology
MH  - Lymphoma, T-Cell, Cutaneous/ultrastructure/*virology
MH  - Mycosis Fungoides/virology
MH  - Oligonucleotides, Antisense/pharmacology
MH  - RNA, Viral/analysis
MH  - Skin/virology
MH  - Skin Neoplasms/ultrastructure/*virology
EDAT- 2001/10/12 10:00
MHDA- 2001/11/03 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2001/11/03 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - 10.1111/j.1749-6632.2001.tb03713.x [doi]
PST - ppublish
SO  - Ann N Y Acad Sci. 2001 Sep;941:86-96. doi: 10.1111/j.1749-6632.2001.tb03713.x.