PMID- 11594653
OWN - NLM
STAT- MEDLINE
DCOM- 20020117
LR  - 20191105
IS  - 0952-4746 (Print)
IS  - 0952-4746 (Linking)
VI  - 21
IP  - 3
DP  - 2001 Sep
TI  - Effect of a vitamin D3-based nutritional supplement ('Videchol') on carbohydrate 
      metabolism of rats following chronic low dose-rate irradiation.
PG  - 269-76
AB  - In this study we evaluated the effects of the administration of a vitamin D3 
      preparation 'Videchol' to chronically irradiated rats (1 cGy day(-1)) by the 
      assessment of the activities of several glycolytic enzymes: lactic dehydrogenase 
      (LDH) (EC 1.1.1.28), pyruvate kinase (PK) (EC 2.7.1.40) and hexokinase (HK) (EC 
      2.7.1.1), in populations of erythroid and myeloid bone marrow cells. Videchol 
      treatment of irradiated rats led to the normalisation of HK and LDH activity at 
      cumulative doses of around 30 cGy in granulocyte-monocyte cells and to 
      normalisation of LDH and PK activities in erythroid cells starting at 20 cGy in 
      comparison with irradiated rats who did not receive Videchol. The reaction 
      kinetic parameters of LDH in erythrocytes changed according to the redistribution 
      pattern of the isozymes throughout the different stages of the experiment. The 
      administration of Videchol to irradiated rats led to a rearrangement of the LDH 
      isozymes ratio characterised by kinetic properties more comparable to those of 
      the controls. Thus, vitamin D3 appears to induce a normalisation of carbohydrate 
      metabolism in rats chronically irradiated with low dose-rate ionising radiation.
FAU - Starikovich, L S
AU  - Starikovich LS
AD  - Lviv Ivan Franko National University, Department of Biochemistry, Lviv, Ukraine.
FAU - Aragon, G A
AU  - Aragon GA
FAU - Vernikovska, Y I
AU  - Vernikovska YI
FAU - Vigovska, T V
AU  - Vigovska TV
FAU - Veliky, M M
AU  - Veliky MM
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - England
TA  - J Radiol Prot
JT  - Journal of radiological protection : official journal of the Society for 
      Radiological Protection
JID - 8809257
RN  - 0 (Isoenzymes)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - EC 1.1.1.27 (L-Lactate Dehydrogenase)
RN  - EC 2.7.1.1 (Hexokinase)
RN  - EC 2.7.1.40 (Pyruvate Kinase)
SB  - IM
MH  - Animals
MH  - Bone Marrow/drug effects/*metabolism
MH  - Cholecalciferol/*pharmacology
MH  - Erythrocytes/drug effects/*metabolism
MH  - Glycolysis/*radiation effects
MH  - Hexokinase/metabolism
MH  - Isoenzymes/metabolism
MH  - L-Lactate Dehydrogenase/metabolism
MH  - Pyruvate Kinase/metabolism
MH  - Radiation Dosage
MH  - Rats
MH  - Rats, Wistar
MH  - Whole-Body Irradiation
EDAT- 2001/10/12 10:00
MHDA- 2002/01/18 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/01/18 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - 10.1088/0952-4746/21/3/305 [doi]
PST - ppublish
SO  - J Radiol Prot. 2001 Sep;21(3):269-76. doi: 10.1088/0952-4746/21/3/305.