PMID- 11594770
OWN - NLM
STAT- MEDLINE
DCOM- 20011207
LR  - 20061115
IS  - 0006-291X (Print)
IS  - 0006-291X (Linking)
VI  - 288
IP  - 1
DP  - 2001 Oct 19
TI  - Molecular cloning and characterization of mouse Tspan-3, a novel member of the 
      tetraspanin superfamily, expressed on resting dendritic cells.
PG  - 178-83
AB  - Dendritic cells (DCs) are the most potent antigen-presenting cells and play an 
      essential role for triggering T-cell-mediated immune responses. In search for 
      novel cell surface molecules expressed on DCs involved in T cell priming by 
      representational differential analysis, we identified a mouse homologue of 
      Tspan-3 (mTspan-3), a novel member of the tetraspanin superfamily. The mTspan-3 
      consists of four hydrophobic, putative transmembrane regions, forming a small and 
      a large extracellular loop, with short intracellular amino and carboxil tails. 
      Although the mTspan-3 is expressed on a variety of immune cell types including 
      resting DCs, its expression on DCs is downregulated during activation induced by 
      cross-linking CD40 with anti-CD40 monoclonal antibody. These results suggest that 
      mTspan-3 may be involved in the function of DCs in association with T cell 
      stimulation.
CI  - Copyright 2001 Academic Press.
FAU - Tokoro, Y
AU  - Tokoro Y
AD  - Department of Immunology, Institute of Basic Medical Sciences, Institute of 
      Clinical Medicine, 1-1-1 Tennodai, Tsukuba Science City, Ibaraki 305-8575, Japan.
FAU - Shibuya, K
AU  - Shibuya K
FAU - Osawa, M
AU  - Osawa M
FAU - Tahara-Hanaoka, S
AU  - Tahara-Hanaoka S
FAU - Iwama, A
AU  - Iwama A
FAU - Kitamura, T
AU  - Kitamura T
FAU - Nakauchi, H
AU  - Nakauchi H
FAU - Shibuya, A
AU  - Shibuya A
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - Biochem Biophys Res Commun
JT  - Biochemical and biophysical research communications
JID - 0372516
RN  - 0 (Membrane Proteins)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Amino Acid Sequence
MH  - Animals
MH  - Cell Line
MH  - Cells, Cultured
MH  - Cloning, Molecular
MH  - Dendritic Cells/*immunology
MH  - Down-Regulation
MH  - Lymphocyte Activation
MH  - Membrane Proteins/chemistry/*genetics/*metabolism
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Molecular Sequence Data
MH  - Protein Structure, Tertiary
MH  - RNA, Messenger/biosynthesis
MH  - Sequence Homology, Amino Acid
MH  - T-Lymphocytes/immunology
MH  - Tissue Distribution
MH  - Transcription, Genetic
EDAT- 2001/10/12 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - S0006-291X(01)95742-0 [pii]
AID - 10.1006/bbrc.2001.5742 [doi]
PST - ppublish
SO  - Biochem Biophys Res Commun. 2001 Oct 19;288(1):178-83. doi: 
      10.1006/bbrc.2001.5742.