PMID- 11595212
OWN - NLM
STAT- MEDLINE
DCOM- 20011212
LR  - 20190614
IS  - 0006-8993 (Print)
IS  - 0006-8993 (Linking)
VI  - 915
IP  - 2
DP  - 2001 Oct 12
TI  - Correlation between hippocampal BDNF mRNA expression and memory performance in 
      senescent rats.
PG  - 227-33
AB  - Brain-derived neurotrophic factor (BDNF) has been suggested to be involved in 
      memory processes. In the present study, the association between memory impairment 
      at senescence and BDNF expression in the hippocampus was studied in 
      30-32-month-old Brown Norway rats, which had been maternally deprived early in 
      life. These animals display a bimodal distribution in their spatial learning 
      ability: rats are either non-impaired or impaired. BDNF mRNA expression in the 
      hippocampus was compared between non-impaired and impaired rats. We measured BDNF 
      mRNA expression in the hippocampus 3 h after training in the Morris water maze 
      ('post-training') and at 1 month after training ('basal'). Non-impaired 
      performers displayed a higher post-training BDNF mRNA level in the CA1 region 
      than impaired rats. In addition, only in the non-impaired performers 
      post-training BDNF mRNA levels in CA1 and dentate gyrus were increased as 
      compared to basal levels. Thus, we have demonstrated that in senescent rats, 
      hippocampal BDNF expression in response to water maze training is associated with 
      memory performance.
FAU - Schaaf, M J
AU  - Schaaf MJ
AD  - Leiden/Amsterdam Center for Drug Research, Division of Medical Pharmacology, 
      Sylvius Laboratories. P.O. Box 9503, 2300 RA, Leiden, The Netherlands. 
      schaaf@niehs.nih.gov
FAU - Workel, J O
AU  - Workel JO
FAU - Lesscher, H M
AU  - Lesscher HM
FAU - Vreugdenhil, E
AU  - Vreugdenhil E
FAU - Oitzl, M S
AU  - Oitzl MS
FAU - de Kloet, E R
AU  - de Kloet ER
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Brain Res
JT  - Brain research
JID - 0045503
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - 0 (RNA, Messenger)
SB  - IM
MH  - Aging/*genetics/physiology
MH  - Animals
MH  - Brain-Derived Neurotrophic Factor/*biosynthesis/genetics
MH  - Female
MH  - Gene Expression Regulation/*physiology
MH  - Hippocampus/*metabolism
MH  - In Situ Hybridization
MH  - Male
MH  - Maternal Deprivation
MH  - Maze Learning/physiology
MH  - Memory/*physiology
MH  - RNA, Messenger/*biosynthesis
MH  - Rats
MH  - Rats, Inbred BN
EDAT- 2001/10/12 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - S0006899301028554 [pii]
AID - 10.1016/s0006-8993(01)02855-4 [doi]
PST - ppublish
SO  - Brain Res. 2001 Oct 12;915(2):227-33. doi: 10.1016/s0006-8993(01)02855-4.