PMID- 11595343 OWN - NLM STAT- MEDLINE DCOM- 20020115 LR - 20190701 IS - 0304-3940 (Print) IS - 0304-3940 (Linking) VI - 312 IP - 2 DP - 2001 Oct 19 TI - Preservation of neurotrophin expression in microglia that migrate into the gerbil's brain across the blood-brain barrier. PG - 95-8 AB - Microglia isolated from a mixed glial culture drawn from neonatal Mongolian gerbils were demonstrated to produce high amounts of brain-derived neurotrophic factor (BDNF) and glial cell line-derived neurotrophic factor (GDNF). The gerbil microglia retained the capability to migrate into the brain parenchyma after intra-arterial injection. We found that exogenously migrated microglia retained their BDNF and GDNF productive ability and expressed large amounts of BDNF and GDNF in damaged brain areas which suggests microglia's role as a protectant of damaged neurons. Since peripherally injected microglia exhibit specific affinity for areas of neural damage within the brain, we suggest that microglia are possible tools for cell therapy of brain damage. FAU - Suzuki, H AU - Suzuki H AD - Institute for Comprehensive Medical Science, Fujita Health University, Toyoake, Aichi 470-1192, Japan. FAU - Imai, F AU - Imai F FAU - Kanno, T AU - Kanno T FAU - Sawada, M AU - Sawada M LA - eng PT - Journal Article PL - Ireland TA - Neurosci Lett JT - Neuroscience letters JID - 7600130 RN - 0 (Brain-Derived Neurotrophic Factor) RN - 0 (Fluorescent Dyes) RN - 0 (Glial Cell Line-Derived Neurotrophic Factor) RN - 0 (Nerve Growth Factors) RN - 0 (Nerve Tissue Proteins) RN - 0 (Organic Chemicals) RN - 0 (PKH 26) RN - 82115-62-6 (Interferon-gamma) SB - IM MH - Animals MH - Animals, Newborn MH - Blood-Brain Barrier/*physiology MH - Brain/cytology/metabolism/*surgery MH - Brain Injuries/metabolism/physiopathology/*therapy MH - Brain Tissue Transplantation/*methods MH - Brain-Derived Neurotrophic Factor/metabolism MH - Cell Movement/drug effects/*physiology MH - Cells, Cultured/drug effects/metabolism/transplantation MH - Fluorescent Dyes MH - Gerbillinae MH - Glial Cell Line-Derived Neurotrophic Factor MH - Hippocampus/cytology/metabolism MH - Immunohistochemistry MH - Interferon-gamma/pharmacology MH - Male MH - Microglia/drug effects/metabolism/*transplantation MH - Nerve Growth Factors/*metabolism MH - Nerve Tissue Proteins/metabolism MH - *Organic Chemicals EDAT- 2001/10/12 10:00 MHDA- 2002/01/16 10:01 CRDT- 2001/10/12 10:00 PHST- 2001/10/12 10:00 [pubmed] PHST- 2002/01/16 10:01 [medline] PHST- 2001/10/12 10:00 [entrez] AID - S0304-3940(01)02198-X [pii] AID - 10.1016/s0304-3940(01)02198-x [doi] PST - ppublish SO - Neurosci Lett. 2001 Oct 19;312(2):95-8. doi: 10.1016/s0304-3940(01)02198-x.