PMID- 11596096
OWN - NLM
STAT- MEDLINE
DCOM- 20011221
LR  - 20061115
IS  - 0146-6615 (Print)
IS  - 0146-6615 (Linking)
VI  - 65
IP  - 3
DP  - 2001 Nov
TI  - Human herpesvirus 6 downregulates major histocompatibility complex class I in 
      dendritic cells.
PG  - 576-83
AB  - The expression of major histocompatibility complex (MHC) class I, class II, CD1a, 
      and CD 83 in dendritic cells (DCs) after infection with human herpesvirus 6 
      (HHV-6) was examined. Whereas there was no significant change in the expression 
      of CD1a, CD83, and MHC class II in infected DCs, MHC class I expression was 
      downregulated after infection with HHV-6 variant A but not HHV-6B. The expression 
      of HHV-6 immediate-early or early genes was required for the downregulation of 
      MHC class I. The de novo synthesis of MHC class I was greatly suppressed by 
      infection with HHV-6A in DCs, while its rate of degradation was only slightly 
      elevated. These results suggest that HHV-6A may escape from the host immune 
      system in DCs by causing the downregulation of MHC class I synthesis.
CI  - Copyright 2001 Wiley-Liss, Inc.
FAU - Hirata, Y
AU  - Hirata Y
AD  - Department of Microbiology, Osaka University Medical School, Yamada-oka, Suita, 
      Osaka 565-0871, Japan.
FAU - Kondo, K
AU  - Kondo K
FAU - Yamanishi, K
AU  - Yamanishi K
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - United States
TA  - J Med Virol
JT  - Journal of medical virology
JID - 7705876
RN  - 0 (Cytokines)
RN  - 0 (Histocompatibility Antigens Class I)
SB  - IM
MH  - Cells, Cultured
MH  - Cytokines/metabolism/pharmacology
MH  - Dendritic Cells/*immunology/*virology
MH  - Down-Regulation
MH  - Flow Cytometry
MH  - Herpesvirus 6, Human/*pathogenicity/physiology
MH  - Histocompatibility Antigens Class I/*biosynthesis
MH  - Humans
MH  - Precipitin Tests
MH  - Virus Replication
EDAT- 2001/10/12 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/12 10:00
PHST- 2001/10/12 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/12 10:00 [entrez]
AID - 10.1002/jmv.2075 [pii]
PST - ppublish
SO  - J Med Virol. 2001 Nov;65(3):576-83.