PMID- 11600201
OWN - NLM
STAT- MEDLINE
DCOM- 20020125
LR  - 20190826
IS  - 0165-2478 (Print)
IS  - 0165-2478 (Linking)
VI  - 79
IP  - 3
DP  - 2001 Dec 3
TI  - Enhanced IL-18 expression in common skin tumors.
PG  - 215-9
AB  - Interleukin-18 (IL-18) has been found to have multiple effects upon various cells 
      involved in inflammatory response. Recently we reported that B16 murine melanoma 
      cells are able to produce IL-18, which is involved in the regulation of 
      intracellular reactive oxygen intermediates (ROI) and Fas-ligand expression, 
      indicating that IL-18 plays key role in the tumor activity of melanoma. In this 
      study, we investigated the pattern of IL-18 expression in the human system. IL-18 
      production was tested by enzyme linked immunosorbent assay (ELISA) assay in 
      various tumor cell lines, including Raji (Burkitt's lymphoma), IM-9 (B 
      lymphoblast), Jurkat (acute T cell leukemia), SK-MES-1 (squamous cell carcinoma 
      (SCC) cell line), SK-MEL-2, G-361, DM-4, and DX-3 (melanoma cell lines). ELISA 
      tests showed that IL-18 was highly expressed in malignant skin tumors such as 
      SK-MES-1, SK-MEL-2, G-361, DM-4, and DX-3 cell lines, thus suggesting that IL-18 
      production may be associated with the malignancy of skin tumors. Here, we report 
      that enhanced IL-18 expression is positively correlated with malignant skin 
      tumors such as SCC and melanoma, suggesting the importance role of IL-18 in 
      malignancy of skin tumors. Taken together, expression of IL-18 by tumor cells in 
      human skin tissue may provide an important clue to understand the pathogenesis of 
      malignant skin tumors.
FAU - Park, H
AU  - Park H
AD  - Department of Dermatology, St. Mary's Hospital, The Catholic University of Korea, 
      Seoul, South Korea.
FAU - Byun, D
AU  - Byun D
FAU - Kim, T S
AU  - Kim TS
FAU - Kim, Y I
AU  - Kim YI
FAU - Kang, J S
AU  - Kang JS
FAU - Hahm, E S
AU  - Hahm ES
FAU - Kim, S H
AU  - Kim SH
FAU - Lee, W J
AU  - Lee WJ
FAU - Song, H K
AU  - Song HK
FAU - Yoon, D Y
AU  - Yoon DY
FAU - Kang, C J
AU  - Kang CJ
FAU - Lee, C
AU  - Lee C
FAU - Houh, D
AU  - Houh D
FAU - Kim, H
AU  - Kim H
FAU - Cho, B
AU  - Cho B
FAU - Kim, Y
AU  - Kim Y
FAU - Yang, Y H
AU  - Yang YH
FAU - Min, K H
AU  - Min KH
FAU - Cho, D H
AU  - Cho DH
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - Immunol Lett
JT  - Immunology letters
JID - 7910006
RN  - 0 (Culture Media, Conditioned)
RN  - 0 (Interleukin-18)
RN  - 82115-62-6 (Interferon-gamma)
SB  - IM
MH  - Carcinoma, Basal Cell/immunology/metabolism
MH  - Carcinoma, Squamous Cell/immunology/metabolism
MH  - Culture Media, Conditioned/pharmacology
MH  - Enzyme-Linked Immunosorbent Assay
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Immunohistochemistry
MH  - Interferon-gamma/biosynthesis
MH  - Interleukin-18/*biosynthesis/immunology
MH  - Killer Cells, Natural/drug effects/metabolism
MH  - Melanoma/immunology/metabolism
MH  - Skin Neoplasms/immunology/*metabolism
MH  - Tumor Cells, Cultured
EDAT- 2001/10/16 10:00
MHDA- 2002/01/26 10:01
CRDT- 2001/10/16 10:00
PHST- 2001/10/16 10:00 [pubmed]
PHST- 2002/01/26 10:01 [medline]
PHST- 2001/10/16 10:00 [entrez]
AID - S0165247801002784 [pii]
AID - 10.1016/s0165-2478(01)00278-4 [doi]
PST - ppublish
SO  - Immunol Lett. 2001 Dec 3;79(3):215-9. doi: 10.1016/s0165-2478(01)00278-4.