PMID- 11601199
OWN - NLM
STAT- MEDLINE
DCOM- 20011211
LR  - 20071115
IS  - 0253-2727 (Print)
IS  - 0253-2727 (Linking)
VI  - 20
IP  - 2
DP  - 1999 Feb
TI  - [Study of TEL-AML1 fusion gene in childhood B-lineage acute lymphoblastic 
      leukemia].
PG  - 61-4
AB  - OBJECTIVE: To determine the incidence of TEL-AML1 fusion gene and its role in 
      clinical diagnosis and prognosis of childhood B-lineage acute lymphoblastic 
      leukemia (B-ALL), and to compare the two techniques: nested RT-PCR and dual-color 
      fluorescence in situ hybridization (FISH). METHODS: Nested RT-PCR and dual-color 
      FISH techniques were used to detect TEL-AML1 fusion gene. RESULTS AND CONCLUSION: 
      TEL-AML1 fusion transcript was found in 22.5%(9/40) of patients with B-ALL by 
      RT-PCR. The prognosis of these TEL-AML1 positive patients was relatively good and 
      the complete remission rate was 100%. Both RT-PCR and FISH techniques were proved 
      to be useful for detecting TEL-AML1 fusion gene and suitable for clinical 
      diagnosis and prognosis evaluation.
FAU - Niu, C
AU  - Niu C
AD  - Shanghai Institute of Hematology, Ruijin Hospital, Shanghai Second Medical 
      University, Shanghai 200025.
FAU - Huang, W
AU  - Huang W
FAU - Su, X
AU  - Su X
LA  - chi
PT  - English Abstract
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Zhonghua Xue Ye Xue Za Zhi
JT  - Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi
JID - 8212398
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Oncogene Proteins, Fusion)
RN  - 0 (TEL-AML1 fusion protein)
SB  - IM
MH  - Adolescent
MH  - Burkitt Lymphoma/*genetics
MH  - Child
MH  - Child, Preschool
MH  - Chromosomes, Human, Pair 12
MH  - Chromosomes, Human, Pair 21
MH  - Core Binding Factor Alpha 2 Subunit
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - In Situ Hybridization, Fluorescence
MH  - Infant
MH  - Male
MH  - Oncogene Proteins, Fusion/*genetics
MH  - Precursor Cell Lymphoblastic Leukemia-Lymphoma/*genetics
MH  - Prognosis
MH  - Reverse Transcriptase Polymerase Chain Reaction
EDAT- 2001/10/17 10:00
MHDA- 2002/01/05 10:01
CRDT- 2001/10/17 10:00
PHST- 2001/10/17 10:00 [pubmed]
PHST- 2002/01/05 10:01 [medline]
PHST- 2001/10/17 10:00 [entrez]
PST - ppublish
SO  - Zhonghua Xue Ye Xue Za Zhi. 1999 Feb;20(2):61-4.